Diltiazem Powder: A Complete Guide for Researchers, Pharmacists, and Educators
Introduction
Diltiazem powder is a pharmaceutical compound belonging to the calcium channel blocker class of drugs. It is primarily used to treat hypertension (high blood pressure), angina (chest pain), and certain heart rhythm disorders. In its pure powdered form, Diltiazem is used in pharmaceutical manufacturing, compounding, and scientific research. Factory Price Diltiazem powder/ CAS: 42399-41-7/ wholesale supply
This guide provides an in-depth overview of Diltiazem powder, including its properties, uses, safety data, and regulatory compliance, helping researchers and professionals understand how to handle it safely and ethically. Factory Price Diltiazem powder/ CAS: 42399-41-7/ wholesale supply
What Is Diltiazem Powder?
Diltiazem (chemical formula C22H26N2O4S) is a benzothiazepine derivative that acts by relaxing blood vessels and reducing the workload on the heart. It slows the electrical conduction in the heart, helping control heart rate and improve oxygen delivery to cardiac muscles.
In powder form, Diltiazem is used in formulation laboratories to create:
- Extended-release capsules and tablets
- Injectable preparations (under regulated conditions)
- Reference standards for pharmaceutical testing
- Analytical calibration in pharmacological studies
🧪 Chemical Properties of Diltiazem
| Property | Description |
|---|---|
| Chemical Name | Diltiazem Hydrochloride |
| Molecular Formula | C22H26N2O4S·HCl |
| Molecular Weight | 450.97 g/mol |
| Appearance | White to off-white crystalline powder |
| Solubility | Freely soluble in water and methanol |
| Storage Temperature | 20°C to 25°C (room temperature) |
| pH (1% solution) | 4.0–5.5 |
| Stability | Stable under dry conditions, light-sensitive |
| CAS Number | 42399-41-7 |
How Diltiazem Works (Mechanism of Action)
Diltiazem blocks voltage-dependent calcium channels in the heart and smooth muscles. By limiting calcium ion entry, it:
- Reduces myocardial oxygen demand
- Relaxes vascular smooth muscle
- Lowers blood pressure
- Decreases heart rate and cardiac workload
This dual action on both cardiac and vascular tissues makes Diltiazem unique among calcium channel blockers. Factory Price Diltiazem powder/ CAS: 42399-41-7/ wholesale supply
Applications in Research and Medicine
Diltiazem powder has several legitimate scientific and medical uses, including:
1. Pharmaceutical Compounding
Used in hospitals and pharmacies to prepare customized formulations, especially for patients who require specific doses or delivery systems (such as extended-release tablets).
2. Analytical Chemistry
Serves as a reference standard in high-performance liquid chromatography (HPLC), spectroscopy, and dissolution testing.
3. Cardiovascular Research
Researchers study Diltiazem to understand calcium signaling, cardiac muscle contraction, and drug-drug interactions in cardiovascular diseases.
4. Pharmacokinetic Studies
It helps in evaluating drug absorption, metabolism, and excretion under controlled research environments.
⚕️ Safety and Handling Guidelines
| Category | Guideline / Information |
|---|---|
| Hazard Classification | Non-flammable, low acute toxicity, may cause eye/skin irritation |
| PPE (Personal Protective Equipment) | Lab coat, gloves, eye protection, and mask |
| Spill Response | Absorb with inert material, avoid dust inhalation, clean with water and detergent |
| First Aid | Flush skin/eyes with water for 15 min; seek medical care if irritation persists |
| Inhalation Risk | Avoid dust formation; use in fume hood or ventilated area |
| Waste Disposal | Dispose as pharmaceutical waste via authorized channels |
| Stability | Keep container tightly closed; protect from moisture and light |
Note: Always refer to the official Safety Data Sheet (SDS) for Diltiazem Hydrochloride before handling or disposal.
⚖️ Legal and Regulatory Considerations
Diltiazem is a prescription-only medication regulated under pharmaceutical laws in most countries. It cannot be sold or distributed without appropriate authorization.
- FDA (U.S.): Listed as an approved cardiovascular medication; requires GMP-certified handling.
- EMA (Europe): Controlled as an active pharmaceutical ingredient (API).
- WHO: Recognized as an essential medicine for treating hypertension and angina.
Researchers and manufacturers must:
- Obtain material only from licensed suppliers
- Maintain proper chain-of-custody and storage records
- Follow Good Laboratory Practice (GLP) and Good Manufacturing Practice (GMP) guidelines
🧾 How Licensed Entities Obtain Diltiazem Powder
Here’s the standard compliant process for institutions acquiring pharmaceutical-grade Diltiazem powder:
| Step | Action |
|---|---|
| 1 | Verify supplier credentials (GMP, ISO, FDA-approved) |
| 2 | Submit purchase request via institutional procurement office |
| 3 | Provide research or manufacturing license documentation |
| 4 | Review safety and storage requirements (SDS review) |
| 5 | Receive shipment under controlled temperature and logging |
| 6 | Store according to regulatory standards (pharmacy-grade containment) |
| 7 | Record usage, batch number, and disposal details |
🧠 Research Insights and Benefits
Recent pharmacological studies have shown that Diltiazem not only aids in cardiovascular treatment but also exhibits potential protective effects on:
- Endothelial function
- Cardiac arrhythmia prevention
- Post-infarction remodeling
Its slow calcium channel-blocking properties make it a valuable reference compound for exploring next-generation cardiovascular drugs.
⚠️ Side Effects (When Used Clinically)
In prescribed medical use, common side effects can include:
- Dizziness or fatigue
- Swelling of the ankles
- Slow heart rate (bradycardia)
- Gastrointestinal discomfort
Such effects are dose-dependent and managed by qualified healthcare providers. Factory Price Diltiazem powder/ CAS: 42399-41-7/ wholesale supply
✅ Summary
Diltiazem powder plays a crucial role in cardiovascular research, pharmaceutical development, and academic education. When handled under licensed conditions, it provides a safe and effective way to study calcium channel modulation and heart physiology. Factory Price Diltiazem powder/ CAS: 42399-41-7/ wholesale supply
However, due to its regulatory status as an active pharmaceutical ingredient (API), Diltiazem must only be acquired and used by licensed institutions, pharmacies, or certified researchers in compliance with national and international pharmaceutical laws.
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