Buy 2,6-Dioxopiperidine-3-ammonium Chloride (CAS: 24666-56-6): Properties, Uses, and Safe Procurement Guide
Introduction
2,6-Dioxopiperidine-3-ammonium chloride is a heterocyclic organic compound widely used as an intermediate in pharmaceutical synthesis, organic chemistry, and fine-chemical manufacturing. As a member of the piperidine derivative family, it serves as a versatile building block in the creation of biologically active molecules, specialty reagents, and lactam-based drug intermediates.
Featuring two carbonyl groups at the 2- and 6-positions and a protonated amine paired with chloride, the compound exhibits high stability, strong solubility in polar solvents, and reliable performance in condensation, acylation, and amidation reactions. These attributes make it valuable in both industrial synthesis and academic research.
Chemical Properties
Table: Chemical and Physical Characteristics
| Property | Details |
|---|---|
| Chemical Name | 2,6-Dioxopiperidine-3-ammonium chloride |
| Synonyms | Succinimide-3-ammonium chloride, 3-Aminoglutaramide hydrochloride |
| Molecular Formula | C?H?ClN?O? |
| Molecular Weight | 164.59 g/mol (approx.) |
| CAS Number | 24666-56-6 (verify for specific salt forms) |
| Appearance | White to off-white crystalline powder |
| Solubility | Soluble in water and polar organic solvents |
| Melting Point | 210–220°C (decomposition) |
| Stability | Stable at ambient temperature; hygroscopic upon exposure |
| Storage | Keep tightly sealed in a cool, dry environment |
| Safety | Non-flammable; standard laboratory PPE required |
Additional chemical descriptors:
- Exact Mass: 164.0352552
- Topological Polar Surface Area: 72.2 Ų
- Hydrogen Bond Donors: 3
- Hydrogen Bond Acceptors: 3
Role in Research and Industry
1. Pharmaceutical & API Intermediate
2,6-Dioxopiperidine-3-ammonium chloride is commonly used in the synthesis of:
- Lactam-based pharmaceuticals
- Nitrogen-containing heterocycles
- Enzyme inhibitors
- Neurological and immunomodulatory drug precursors
Notably, it is a recognized intermediate in the preparation of lenalidomide and related therapeutic compounds.
2. Organic Chemistry Applications
This compound performs effectively in:
- Nucleophilic substitution
- Amide bond formation
- Ring-opening and rearrangement reactions
- Construction of heterocyclic scaffolds used in medicinal chemistry
Because of its structural reactivity, chemists often use it in mechanism studies involving tautomerism or lactam–amide conversions.
3. Academic and Analytical Research
Research laboratories use the compound for:
- Reaction mechanism modeling
- Tautomerism and intramolecular hydrogen bonding studies
- Heterocycle reactivity experiments
- Database referencing (PubChem, Reaxys, ChemSpider)
Its stable crystalline form makes it convenient for benchmarking and method development.
Commercial and Industrial Insights
2,6-Dioxopiperidine-3-ammonium chloride is produced by fine-chemical manufacturers in controlled batches. Reputable suppliers typically provide:
- ?98% purity
- Certificate of Analysis (COA)
- Material Safety Data Sheet (MSDS)
- Batch traceability
- GMP/ISO compliance documentation (depending on intended application)
Market Use Cases
- Pharmaceutical R&D laboratories
- Academic institutions
- Industrial organic synthesis
- Custom synthesis companies
- API precursor development facilities
Supplier Specifications
| Specification | Details |
|---|---|
| Production Capacity | 20 metric tons/year |
| Packaging | 25 kg/drum (bulk); small-quantity research sizes available |
| Delivery Time | Immediate / in stock |
| Transportation | Sea, air, or express courier |
| Minimum Order | 100 grams |
| Grade | Premium / Industrial grade |
| Form Provided | Hydrochloride salt (HCl form) |
Safe and Legal Procurement Guide
To purchase 2,6-Dioxopiperidine-3-ammonium chloride responsibly and legally, follow the guidelines below.
1. Confirm Your Intended Use
Ensure your application falls within:
- Laboratory research
- Chemical synthesis
- Academic experimentation
- Industrial intermediate manufacturing
2. Verify Supplier Credentials
Choose suppliers that are:
- ISO 9001 or REACH-certified
- Listed in official chemical registries
- Capable of providing MSDS, COA, and batch data
- Established in fine-chemical distribution
Examples include (general categories):
International chemical suppliers, pharma-grade reagent companies, certified distributors.
3. Documentation Requirements
Depending on your region, suppliers may request:
- End-use declaration
- Business or institutional purchase order
- Import/export compliance information
- Hazardous materials handling statements
4. Shipping and Storage
- Transport in sealed, moisture-resistant containers
- Store in a cool, dry location
- Avoid long-term exposure to humidity
- Dispose of waste under local chemical waste regulations
Safety and Handling Information
| Safety Aspect | Guideline |
|---|---|
| PPE | Lab coat, gloves, goggles |
| Exposure Risks | May irritate skin, eyes, or respiratory tract |
| First Aid | Rinse with water; seek medical advice if persistent |
| Waste Disposal | Follow environmental and hazardous waste regulations |
| Fire Safety | Non-flammable; may emit nitrogen oxides when heated strongly |
Conclusion
2,6-Dioxopiperidine-3-ammonium chloride is a valuable intermediate in chemical synthesis, pharmaceutical development, and academic research. Its reactivity, stability, and compatibility with heterocyclic chemistry make it a widely used building block in the creation of advanced organic structures and therapeutic candidates.
When sourced from certified suppliers and handled according to MSDS and regulatory guidelines, it offers reliable performance for legitimate scientific and industrial applications.
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