Canrenone Powder: Properties, Uses, and Legal Access for Research and Pharmaceutical Applications
Introduction
Canrenone is a steroidal compound classified as a mineralocorticoid receptor antagonist. It is a biologically active metabolite of spironolactone, widely studied in pharmaceutical research, endocrinology, and cardiovascular medicine.
Canrenone Powder is used primarily for laboratory research, drug development studies, and analytical standards, making it valuable for medical researchers, pharmaceutical companies, and regulatory laboratories.
This article covers chemical properties, pharmacological relevance, research applications, quality standards, and legal procurement, ensuring compliance and proper use.
Informational: Chemical Identity and Properties
| Parameter | Specification |
|---|---|
| Chemical Name | Canrenone |
| Synonyms | 7?-Thiomethylspironolactone metabolite; Canrenoic ketone |
| CAS Number | 2278-81-4 |
| Molecular Formula | C22H28O4S |
| Molecular Weight | 388.52 g/mol |
| Appearance | White to off-white crystalline powder |
| Melting Point | 128–132 °C |
| Solubility | Soluble in DMSO, ethanol; slightly soluble in water |
| Storage Conditions | Cool, dry, and dark place; airtight container |
| Purity | ? 98% (HPLC for analytical/research grade) |
| Documentation | Certificate of Analysis (COA), Safety Data Sheet (SDS) |
Overview: Canrenone is a steroidal lactone with potent antimineralocorticoid activity, making it a key compound in cardiovascular and renal pharmacology research.
Navigational: Pharmacological and Research Applications Canrenone Powder online
1. Pharmaceutical Research
- Used to study diuretic and antihypertensive mechanisms.
- Serves as a reference compound in the development of spironolactone analogs.
- Investigated for aldosterone antagonism and cardioprotective effects.
2. Endocrinology and Clinical Studies
- Supports research on mineralocorticoid receptor regulation.
- Used in studies of electrolyte balance, sodium retention, and potassium homeostasis.
- Employed to explore metabolic pathways of steroidal diuretics.
3. Analytical Chemistry Applications
- Functions as a standard for HPLC, LC-MS, and NMR analysis.
- Assists in metabolite profiling and quantification studies.
- Useful for method validation in pharmacokinetic and bioanalytical assays.
4. Industrial and Academic Use
- Provides high-purity reference material for drug development labs.
- Serves in educational demonstrations of steroidal pharmacology and biochemistry.
Commercial: Quality Standards and Supplier Considerations
1. Available Grades
| Grade | Purity | Application |
|---|---|---|
| Analytical/Research Grade | ? 98% | Laboratory and pharmacological research |
| Pharmaceutical Grade | ? 99% | Drug development and regulatory studies |
| Bulk/Industrial Grade | 95–98% | Large-scale analytical or R&D purposes |
2. Packaging and Documentation
- Typically supplied in sealed glass vials or HDPE containers (10 mg – 1 kg).
- Batch-specific COA and SDS provided for each shipment.
- Nitrogen-flushed packaging recommended for long-term stability.
3. Quality Assurance
- Purity confirmed via HPLC, LC-MS, or NMR analysis.
- Free from heavy metals and residual solvents.
- Supplier certification (ISO or GMP) ensures consistent and reliable product quality.
Transactional: Legal Supply and Procurement of Canrenone Powder near
Canrenone Powder is a research chemical and pharmaceutical intermediate, not approved for direct clinical use without regulatory authorization.
Regulatory Overview
| Region | Regulatory Authority | Key Requirements |
|---|---|---|
| United States | FDA, DEA (for research use) | Laboratory and analytical research permitted under controlled conditions |
| European Union | EMA, REACH | Registration for research or industrial use; GMP compliance for pharmaceutical-grade production |
| United Kingdom | MHRA | Permitted for research purposes with proper documentation |
| Asia-Pacific | Local ministries of health and environment | Requires safety data and proof of intended research use |
Safe and Compliant Procurement
- Source from certified suppliers offering research-grade or pharmaceutical-grade Canrenone Powder.
- Verify COA and SDS for each batch to ensure purity and authenticity.
- Ensure that storage, handling, and documentation comply with local chemical safety and environmental regulations.
- Maintain records for auditing purposes and institutional compliance.
Safety and Handling
| Hazard | Precaution |
|---|---|
| Toxicity | Handle as a bioactive research chemical; avoid ingestion or inhalation |
| PPE | Gloves, lab coat, eye protection |
| Storage | Store in a cool, dry, airtight container away from light |
| Handling | Use fume hood or ventilated area; avoid direct contact |
| Disposal | Follow institutional protocols for chemical and bioactive waste |
| First Aid | Rinse skin/eyes thoroughly if contact occurs; seek medical advice |
Note: Canrenone is not for human consumption unless formulated under regulated pharmaceutical protocols.
Market and Research Outlook Canrenone Powder
The global market for steroidal research chemicals is growing steadily due to:
- Increased research into cardiovascular and renal therapeutics.
- Demand for high-purity metabolites of established drugs like spironolactone.
- Expansion in bioanalytical method development and pharmacokinetic studies.
Suppliers providing traceable, certified Canrenone Powder are preferred in research institutions and pharmaceutical R&D laboratories worldwide.
Conclusion Canrenone Powder
Canrenone Powder is an indispensable compound for pharmaceutical research, metabolic studies, and analytical chemistry. Its high purity and stability make it suitable for laboratories conducting drug development, pharmacological assays, and steroid research.
By sourcing from certified suppliers with proper COA and safety documentation, researchers can ensure legal compliance, consistent quality, and safe handling. Canrenone remains a vital tool for advancing cardiovascular and endocrine pharmacology research globally.
Canrenone Powder Keywords
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Buy Wholesale Canrenone Powder (CAS No. 976-71-6)
Canrenone Overview:
Canrenone, a steroidal antimineralocorticoid and an active metabolite of spironolactone, is used primarily as a diuretic. It is marketed under various brand names, including Contaren, Luvion, Phanurane, and Spiroletan. Canrenone is effective in treating conditions related to fluid retention and is a potent antimineralocorticoid. It also contributes to the therapeutic effects of spironolactone.
Medical Uses:
- Diuretic Treatment: Mainly used to manage fluid retention and associated conditions.
- Hirsutism: Effective in treating excessive hair growth in women.
- Heart Failure: Studies indicate a mortality benefit compared to placebo in patients with chronic heart failure.
Pharmacology:
- Potency: More potent as an antimineralocorticoid than spironolactone, but less effective as an antiandrogen.
- Mechanism: Inhibits steroidogenic enzymes such as 11?-hydroxylase and 17?-hydroxylase, although with lower potency than spironolactone.
Packaging Options:
- 1 kg/foil bag
- 25 kg/drum
Delivery:
- Lead Time: 3-5 days
Detailed Quality Specifications:
- Assay: ?98.0% (99.10%)
- Loss on Drying: ?0.6% (0.2%)
- Residue on Ignition: ?0.2% (0.1%)
- Each Impurity: ?0.5% (0.06%)
- Total Impurities: ?1.0% (0.18%)
Where to Buy:
- Research Chem Lab: Canrenone powder for sale
- CP Lab Safety: Canrenone, 25g
- China Suppliers: High-quality Canrenone powder
Contact Us:
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