CDC (ab141560) – Lipoxygenase Inhibitor: Research Applications, Properties, and Legal Handling
Introduction
CDC (ab141560) is a potent and selective lipoxygenase (LOX) inhibitor with applications in cell cycle, inflammation, cancer, and neurodegenerative disease research. Understanding CDC proteins and LOX enzymes is critical for researchers studying molecular signaling, oxidative stress, and pharmacological modulation.
This guide provides:
- Clear scientific context for CDC and LOX research
- Informational tables on molecular properties and lab applications
- Safe handling, storage, and regulatory compliance guidance
What are CDC Proteins?
Cell Cycle (CDC) proteins regulate the cell cycle, ensuring proper DNA replication, mitosis, and cell division. Dysfunction can contribute to cancer and other proliferative disorders.
Key CDC Proteins:
| Protein | Function | Research Relevance |
|---|---|---|
| CDC2 / CDK1 | G2 → M phase transition | Cell cycle regulation, cancer research |
| CDC25 phosphatases | Activate cyclin-dependent kinases | Cell proliferation studies |
| CDC20 | Chromosome segregation | Mitotic checkpoint analysis |
Commercial / Research Relevance: LOX s are primary targets in cancer biology studies and cell cycle assays.
What is Lipoxygenase (LOX)?
Lipoxygenase (LOX) enzymes catalyze oxidation of polyunsaturated fatty acids (PUFAs), generating lipid mediators that regulate inflammation, cell signaling, and oxidative stress.
Research Applications:
- Studying inflammatory pathways
- Anti-inflammatory drug screening
- Food, plant, and agricultural research (e.g., enzymatic browning, pest response)
LOX Interaction: LOX activity influences CDC protein expression, linking cell cycle regulation and inflammatory signaling.
CDC & LOX Research Applications
| Component | Function | Application | Safety / Handling |
|---|---|---|---|
| CDC2/CDK1 | Cell cycle regulation | Cancer research, molecular assays | Lab coat, gloves, BSL-2 compliance |
| CDC25 | CDK activator | Cell proliferation studies | Recombinant protein handling |
| Lipoxygenase | PUFA oxygenation | Drug discovery, inflammation research | Fume hood, PPE, avoid dust |
| LOX inhibitors (CDC ab141560) | Block LOX pathway | Anti-inflammatory drug screening | SDS compliance, PPE |
| LOX substrates | Fatty acids for enzymatic assays | Enzyme kinetics, assay development | Protect from oxidation, light, moisture |
Molecular Information: CDC (ab141560)
| Parameter | Specification |
|---|---|
| Molecular Formula | C18H13NO4 |
| Molecular Weight | 307.30 g/mol |
| CAS Number | 132465-11-3 |
| Appearance | Solid, crystalline powder |
| Storage | -20°C, protect from light and moisture |
| Shelf Life | Long-term stability when stored correctly |
Research Applications of CDC (ab141560)
- Inflammation Studies:
- Inhibits LOX pathways involved in pro-inflammatory signaling
- Useful for modeling inflammatory diseases
- Oxidative Stress:
- Reduces production of lipid hydroperoxides
- Investigates mechanisms of cellular oxidative damage
- Cancer Research:
- Disrupts LOX-mediated signaling in cancer cells
- Evaluates therapeutic potential of LOX inhibition
- Neurodegenerative Disease Research:
- Studies neuroprotective effects in models of Alzheimer’s and Parkinson’s
- Reduces lipid oxidation and inflammatory mediators
Analytical and Experimental Techniques
| Technique | Purpose / Application |
|---|---|
| Western Blot | Detect CDC protein expression |
| Flow Cytometry | Analyze cell cycle stages |
| HPLC / LC-MS | Quantify LOX metabolites |
| CRISPR / Gene Knockdown | Study CDC protein function |
| Enzyme Activity Assays | Measure LOX kinetics |
Legal and Safety Compliance
Regulatory Considerations:
- Only licensed institutions may handle recombinant or LOX inhibitors
- Oversight may include:
- FDA / EMA (clinical relevance)
- Institutional Biosafety Committees (IBC)
- OSHA / local laboratory safety regulations
Laboratory Safety Guidelines:
- Wear gloves, lab coat, goggles
- Use fume hoods for powder handling
- Follow SDS instructions and dispose of waste according to legal and institutional standards
Step-by-Step Research Procurement
- Identify Research Needs: Determine whether your project requires CDC proteins, LOX enzymes, substrates, or inhibitors.
- Find Licensed Suppliers: Use accredited platforms such as Sigma-Aldrich, Thermo Fisher, or Abcam.
- Request Product Information: COA, SDS, purity, and storage requirements are mandatory.
- Place Order Through Approved Channels: Institutional procurement ensures compliance.
- Track Shipment and Storage: Verify temperature control, labeling, and inventory logging.
- Lab Use & Documentation: Record batch, usage, and disposal for reproducibility and audit purposes.
(Research and Commercial Use)
CDC proteins, lipoxygenase enzyme, LOX inhibitors, cell cycle research, inflammation enzyme, molecular biology lab, cancer biomarkers, anti-inflammatory drug targets, enzyme kinetics, laboratory compliance
Conclusion
LOX (ab141560) is a highly specific lipoxygenase inhibitor with critical applications in:
- Inflammation and oxidative stress research
- Cancer biology and therapeutic studies
- Neurodegenerative disease models
Following regulatory guidelines, implementing proper lab safety, and sourcing from licensed suppliers ensures safe, legal, and reproducible research outcomes.
