Androsta-1,4-diene-3,17-dione: Properties, Research Applications, and Legal Access
Introduction
Androsta-1,4-diene-3,17-dione is a steroidal aromatase inhibitor commonly used in pharmaceutical research, endocrine studies, and steroid metabolism analysis. As a precursor in estrogen biosynthesis inhibition, it has applications in drug development and biochemical research.
This article explores its chemical properties, mechanism of action, research applications, quality standards, and legal procurement, ensuring compliance for laboratory and pharmaceutical use.
Informational: Chemical Identity and Properties
| Parameter | Specification |
|---|---|
| Chemical Name | Androsta-1,4-diene-3,17-dione |
| Synonyms | 1,4-Androstadiene-3,17-dione; Aromatase Inhibitor Steroid; ADD |
| CAS Number | 1424-00-6 |
| Molecular Formula | C19H24O2 |
| Molecular Weight | 284.39 g/mol |
| Appearance | White to off-white crystalline powder |
| Melting Point | 149–152 °C |
| Solubility | Soluble in ethanol, methanol, DMSO; slightly soluble in water |
| Purity | ≥ 98% (HPLC/GC) |
| Storage Conditions | –20 °C, dry, light-protected |
| Documentation | Certificate of Analysis (COA), Safety Data Sheet (SDS) |
Overview: Androsta-1,4-diene-3,17-dione is a high-purity steroidal compound, used primarily in research on estrogen biosynthesis, steroid receptor assays, and anti-aromatase studies.
Navigational: Mechanism of Action
Androsta-1,4-diene-3,17-dione functions as a steroidal aromatase inhibitor:
- Inhibition of Aromatase Enzyme: Blocks conversion of androgens (androstenedione and testosterone) to estrogens.
- Endocrine Effects: Reduces estrogen levels, indirectly affecting gonadal and adrenal hormone pathways.
- Pharmacological Relevance: Supports studies on hormone-dependent cancers, estrogen-related metabolic pathways, and steroid receptor interactions.
Understanding its mechanism is essential for research in endocrine therapy, anti-estrogen drug design, and metabolic regulation studies.
Navigational: Research Applications
1. Endocrine and Hormone Research
- Used to study steroid metabolism, estrogen regulation, and aromatase enzyme activity.
- Supports in vitro and in vivo investigations of hormone biosynthesis pathways.
2. Pharmaceutical and Drug Development
- Reference compound for aromatase inhibitor drug testing.
- Evaluates enzyme inhibition kinetics and receptor interactions.
- Useful in developing therapies for hormone-dependent cancers, osteoporosis, and endocrine disorders.
3. Analytical and Anti-Doping Research
- Serves as a standard in GC-MS, LC-MS, and HPLC assays.
- Detects and quantifies exogenous steroid use in biological samples.
4. Educational Applications
- Demonstrates steroid enzyme inhibition and endocrine signaling in academic laboratories.
- Supports learning in pharmacology, biochemistry, and endocrinology courses.
Commercial: Grades, Quality, and Supplier Selection
1. Available Grades
| Grade | Purity | Application |
|---|---|---|
| Analytical / Research Grade | ≥ 98% | Enzyme inhibition studies, receptor assays |
| Pharmaceutical Intermediate | ≥ 99% | Drug development and synthetic pathway research |
| Bulk / Industrial Grade | 95–98% | Large-scale laboratory and R&D studies |
2. Packaging and Handling
- Typically supplied in airtight, light-protected vials (1 mg – 500 g).
- Nitrogen-flushed packaging is recommended for long-term stability.
- Suppliers provide COA, SDS, and batch traceability documentation.
3. Quality Assurance
- Verified using HPLC, GC, or NMR spectroscopy.
- Free from residual solvents and chemical contaminants.
- ISO-certified or GMP-compliant suppliers ensure consistent purity and reproducibility.
Transactional: Legal Supply and Compliance
Androsta-1,4-diene-3,17-dione is a research-grade steroidal compound, legally sold for laboratory, pharmaceutical, and analytical purposes.
Regulatory Overview
| Region | Regulatory Authority | Notes / Requirements |
|---|---|---|
| United States | FDA / DEA | Controlled in some contexts; legal for research and analytical use |
| European Union | EMA / REACH | Legal for laboratory and pharmaceutical research |
| United Kingdom | MHRA | Research use permitted; restricted for human consumption |
| Asia-Pacific | Local authorities | Permitted for R&D; COA and SDS required |
Safe Procurement Practices
- Purchase from certified suppliers providing analytical or pharmaceutical-grade Androsta-1,4-diene-3,17-dione.
- Verify COA and SDS for purity, stability, and batch integrity.
- Store in a cool, dry, airtight, and light-protected environment.
- Use appropriate PPE including gloves, lab coat, and protective eyewear.
- Maintain documentation for institutional and regulatory compliance.
Safety and Handling
| Hazard | Precaution |
|---|---|
| Bioactive Steroid | Avoid ingestion, inhalation, or skin contact |
| PPE | Gloves, lab coat, protective eyewear |
| Storage | –20 °C, dry, light-protected |
| Spills | Absorb and dispose according to local regulations |
| Emergency | Wash affected area; seek medical attention if exposed |
Note: This compound is intended for research purposes only and must not be used for unapproved human administration.
Market and Research Outlook
Androsta-1,4-diene-3,17-dione continues to have strong demand in:
- Endocrine and steroid metabolism research
- Drug development for aromatase inhibitors
- Analytical labs for GC-MS, LC-MS, and HPLC studies
High-purity Androsta-1,4-diene-3,17-dione from certified suppliers ensures safety, reproducibility, and regulatory compliance, making it a key compound for modern pharmaceutical and biochemical research.
Conclusion of Androsta near me
Androsta-1,4-diene-3,17-dione is a vital steroidal aromatase inhibitor used in research on hormone metabolism, enzyme inhibition, and pharmaceutical development.
By sourcing from reputable suppliers with COA and SDS documentation, researchers can ensure legal, safe, and effective use, making it indispensable in steroid research, endocrine studies, and drug development.
Androsta Keywords
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Buy wholesale Androsta-1,4-diene-3,17-dione CAS NO 897-06-3
Uses:
- Research and Development: Commonly used in scientific studies related to steroid hormone research.
- Bulk Drug Intermediates: Utilized in the synthesis of various steroid-based pharmaceuticals.
Product Specifications:
- Purity: Typically 98% or higher.
- Packaging: Usually in foil bags or custom packaging.
- Delivery: Shipped within a few days after payment, via standard shipping methods (e.g., DHL, FedEx).
Ordering Information:
- Minimum Order: Varies by supplier; often starts from a few grams or kilograms depending on your needs.
- Price: Bulk purchasing usually offers significant discounts.
- Storage: Store in a cool, dry place away from light to maintain stability.
Where to Buy:
- Online Suppliers: Look for reputable suppliers with experience in handling bulk steroid intermediates.
- Chemical Book: You can find detailed information and suppliers for Androsta-1,4-diene-3,17-dione on specialized chemical marketplaces and suppliers.
Important Considerations:
- Regulations: Ensure compliance with local regulations regarding the purchase and use of anabolic steroids and related compounds.
- Supplier Verification: Choose suppliers with positive reviews and verified credentials to ensure product quality and reliability.
If you need specific supplier recommendations or further assistance with the purchase, just let me know!
