Progesterone Powder: Properties, Applications, and Regulatory Framework
Introduction
Progesterone powder is a naturally occurring steroidal hormone widely used in pharmaceutical research, hormone replacement therapy (HRT) development, and formulation chemistry. As one of the key hormones regulating the menstrual cycle, fertility, and pregnancy, progesterone also plays essential roles in neuroprotection and metabolic balance.
In its powdered, purified form, progesterone serves as a raw material for analytical research, pharmaceutical compounding, and industrial synthesis — not for direct personal or medical use without prescription authorization.
This article examines the chemical profile, applications, quality standards, and compliance framework of progesterone, providing a roadmap for researchers and licensed buyers seeking legitimate access in accordance with regulatory guidelines.
Informational: Chemical Identity and Properties
Progesterone (CAS No. 57-83-0) belongs to the progestogen class of hormones derived from cholesterol. It is endogenously produced in the ovaries, adrenal glands, and placenta, serving as a critical signaling molecule for reproductive function.
Table 1. Chemical and Physical Properties of Progesterone Powder
| Parameter | Specification |
|---|---|
| IUPAC Name | Pregn-4-ene-3,20-dione |
| Molecular Formula | C₂₁H₃₀O₂ |
| Molecular Weight | 314.47 g/mol |
| Appearance | White or off-white crystalline powder |
| Purity (Pharma/Research Grade) | ≥99% |
| Melting Point | 126–131 °C |
| Solubility | Insoluble in water; soluble in ethanol, chloroform, and oils |
| Stability | Stable at room temperature; sensitive to light and moisture |
| Storage Conditions | 2–8 °C, airtight, light-protected containers |
| Documentation | Certificate of Analysis (COA), Safety Data Sheet (SDS) |
Navigational: Laboratory and Research Applications
Progesterone powder is extensively used in pharmaceutical development, biochemical research, and analytical testing.
1. Pharmaceutical Formulation Research
Scientists employ progesterone powder to develop oral, transdermal, and injectable hormone therapies. Controlled experiments investigate:
- Absorption rates in various delivery systems.
- Molecular stability under different pH conditions.
- Interaction with synthetic analogs for therapeutic innovation.
2. Endocrinology and Reproductive Biology Studies
Research institutions study progesterone’s effects on:
- Endometrial cell differentiation and fertility cycles.
- Neurosteroid pathways related to mood and cognition.
- Bone density and immune modulation in postmenopausal studies.
3. Analytical Chemistry and Quality Control
Progesterone serves as a reference standard in chromatographic and spectroscopic validation:
- HPLC and GC-MS assays for hormone quantification.
- Stability testing in pharmaceutical formulations.
- Comparative analyses against synthetic progestins.
Commercial: Grades, Quality Standards, and Supplier Verification
1. Available Grades
| Grade | Purity Range | Intended Use |
|---|---|---|
| Analytical Reference Standard | ≥99.9% | Calibration and testing |
| Pharmaceutical Grade | ≥99% | API production, compounding (licensed) |
| Research Grade | ≥98% | Laboratory assays and preclinical research |
2. Quality and Compliance Documentation
Reputable suppliers provide:
- GMP-compliant production records
- ISO 9001/13485 certifications
- COA, MSDS, and NMR/HPLC analysis
- Batch traceability and stability data
3. Packaging and Handling
- Sealed in HDPE or amber glass containers under inert atmosphere.
- Light- and moisture-resistant packaging to prevent degradation.
- Transported under temperature-controlled logistics following IATA/UN chemical codes.
Transactional: Regulatory and Legal Framework
Progesterone is a prescription-only hormone in most countries, regulated under pharmaceutical and health safety laws. Its powder form is typically reserved for licensed manufacturing and research facilities.
Table 2. Regulatory Overview
| Region | Regulatory Authority | Control Classification |
|---|---|---|
| United States | FDA / DEA | Schedule IV (Rx-only) |
| European Union | EMA / REACH | Prescription-only, controlled use |
| Canada | Health Canada | Schedule F (requires licensed supplier) |
| Australia | TGA | Schedule 4 (Prescription Medicine) |
| Asia-Pacific | Local Ministries of Health | Restricted chemical; import license required |
Legal Acquisition Path
To purchase progesterone powder legally and ethically, researchers and institutions should:
- Verify supplier credentials (GMP, ISO-certified).
- Submit institutional or pharmaceutical license for procurement.
- Ensure storage, documentation, and waste disposal align with GHS and local health regulations.
- Use only for authorized scientific or manufacturing purposes — not for human self-administration.
Safety and Handling
Progesterone is generally considered low-toxicity under laboratory use but requires standard protective measures.
| Safety Parameter | Precaution |
|---|---|
| Inhalation Risk | Avoid aerosol formation; use fume hood |
| Skin Contact | Wear gloves, lab coat, safety goggles |
| Environmental | Prevent chemical runoff; follow disposal protocol |
| Storage | Store sealed, in cool and dry environment |
| Disposal | Dispose as per biomedical and chemical waste regulations |
Research and Market Outlook
The global progesterone market is driven by rising demand for:
- Fertility treatments and HRT formulations
- Neuroendocrine and metabolic research
- Pharmaceutical intermediates used in controlled synthesis
With expanding applications in women’s health and biochemical R&D, progesterone powder remains a cornerstone material in the development of next-generation progestogenic therapies.
However, growing regulatory oversight underscores the importance of sourcing only from licensed, transparent suppliers adhering to GMP and pharmacovigilance standards.
Conclusion
Progesterone powder serves as a fundamental material in pharmaceutical, biochemical, and analytical research. Its precise chemical profile and biological activity make it invaluable for studying endocrine function and developing therapeutic innovations.
To ensure safety, legality, and research integrity, only licensed institutions should procure progesterone powder — accompanied by comprehensive documentation and compliance verification.
In an era of increasing global regulatory scrutiny, proper handling and ethical sourcing of raw hormones like progesterone are not just requirements — they’re essential for sustainable, responsible scientific progress.
Progesterone powder Keywords
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Applications:
- Pharmaceutical Intermediate: Progesterone is used in the synthesis of other steroids and as a key ingredient in hormone replacement therapy and contraceptives.
- Medical Uses: It is used to treat various conditions such as menstrual disorders, and hormone imbalances, and as part of hormone replacement therapy. It is also used in feminizing hormone therapy and to reduce the risk of uterine or cervical cancer.
- Neurosteroid: Plays a role in brain function as a neurosteroid.
Benefits and Effects:
- Hormonal Balance: Progesterone regulates various physiological processes including the menstrual cycle and pregnancy.
- Sodium Regulation: Elevated progesterone levels can reduce the sodium-retaining activity of aldosterone, influencing fluid balance in the body.
Packaging & Delivery:
- Packaging Options: 25kg/drum, cartons, foil bags, or as per customer requirements.
- Delivery Time: 7 days after payment.
- Shipping: Available by sea, and air, and small quantities can be shipped by DHL, FedEx, EMS, or TNT.
Additional Services:
- Free Samples: Available upon request.
- Professional Guidance: Provided for product usage and application.
- Quality Assurance: High quality and best price guaranteed.
Pricing and Suppliers:
- Wholesale Price: Factory price available. Contact suppliers directly for pricing based on quantity and specific needs.
- Suppliers: Progesterone powder can be purchased from chemical suppliers, pharmaceutical intermediates suppliers, and online marketplaces like Alibaba, IndiaMART, and other industry-specific platforms.
Related Products:
- Micronized Progesterone Powder: Available in various purities including USP grade.
- Progesterone Capsules: For oral administration in hormone therapy.
For specific purchasing inquiries or to place an order, it is recommended to reach out to suppliers or procurement specialists who can assist with pricing, shipping, and additional requirements.
