11α-Hydroxy Canrenone: Properties, Applications, and Legal Supply Access
Introduction
11α-Hydroxy Canrenone is an important steroidal compound belonging to the spironolactone and canrenone family of aldosterone antagonists. It plays a significant role in pharmaceutical research, particularly in the study of diuretic and anti-androgenic mechanisms, metabolic pathways, and steroid biotransformation.
Unlike its clinical relatives (such as spironolactone and canrenone), 11α-Hydroxy Canrenone is primarily used for research and synthesis purposes, helping scientists understand drug metabolism, receptor binding, and biological activity in steroid-based compounds.
This article explores its chemical properties, scientific uses, and regulatory considerations, with guidance for safe, compliant sourcing through certified suppliers.
Informational: Chemical Profile and Characteristics
| Parameter | Specification |
|---|---|
| Chemical Name | 11α-Hydroxy Canrenone |
| CAS Number | 19216-56-9 |
| Molecular Formula | C22H28O4 |
| Molecular Weight | 356.46 g/mol |
| IUPAC Name | (7α,11α,17α)-11,17-Dihydroxy-3-oxo-pregn-4-ene-21-carboxylic acid γ-lactone |
| Synonyms | 11α-Hydroxy-17α-hydroxy-3-oxo-4-pregnen-21-carboxylic acid lactone; Hydroxycanrenone |
| Appearance | White to off-white crystalline powder |
| Purity | ≥ 98% (HPLC) |
| Melting Point | 255–260 °C |
| Solubility | Soluble in ethanol, methanol, chloroform; slightly soluble in water |
| Storage | Keep in cool, dry conditions (2–8°C), protected from light |
| Stability | Stable under recommended storage conditions |
| Documentation | COA, MSDS, NMR/HPLC reports available upon request |
11α-Hydroxy Canrenone is an oxidized metabolite of canrenone, which itself derives from spironolactone—a well-known potassium-sparing diuretic. Its structure includes a γ-lactone ring and hydroxyl groups at specific carbon positions that enhance its binding selectivity to mineralocorticoid receptors.
Navigational: Mechanism and Research Relevance
1. Mechanism of Action
11α-Hydroxy Canrenone acts as an antagonist of the mineralocorticoid receptor (MR), blocking the action of aldosterone—a hormone responsible for sodium retention and potassium excretion in the kidneys.
2. Biological Function
In research models, this compound is investigated for its ability to:
- Inhibit aldosterone binding to MR receptors.
- Promote natriuresis (sodium excretion) while minimizing potassium loss.
- Reduce androgenic activity, relevant to endocrine and metabolic studies.
3. Scientific Value
11α-Hydroxy Canrenone provides insight into:
- Steroid metabolism pathways in liver and kidney tissues.
- Structure-activity relationships (SAR) among aldosterone antagonists.
- Pharmacokinetics and receptor binding in drug development.
Informational: Laboratory and Pharmaceutical Applications
1. Endocrine and Receptor Studies
Used to understand steroid receptor binding dynamics, especially within mineralocorticoid and androgen receptor systems.
2. Drug Metabolism Research
Serves as a metabolite marker in the biotransformation studies of spironolactone and related diuretics, helping identify metabolic intermediates and degradation pathways.
3. Analytical Chemistry Reference Standard
Employed as a HPLC and LC-MS reference compound in pharmaceutical quality control and bioanalytical validation studies.
4. Toxicology and Stability Testing
Researchers use it to assess steroid degradation, metabolite formation, and stability under various chemical or physiological conditions.
Commercial: Availability, Quality, and Packaging
1. Product Grades
| Grade | Purity | Intended Use |
|---|---|---|
| Analytical Standard | ≥ 99% | Instrument calibration, QC analysis |
| Research Grade | ≥ 98% | Laboratory, R&D studies |
| Pharmaceutical Intermediate | ≥ 95% | Bulk synthesis, pre-formulation research |
2. Packaging Options
- Standard: 1 g, 5 g, 10 g vials (sealed under inert atmosphere).
- Bulk: 100 g – 1 kg lots for institutional or industrial research.
- Provided with COA, SDS, and analytical test documentation.
3. Quality Assurance
Each batch of 11α-Hydroxy Canrenone is tested using:
- HPLC purity
- Mass spectrometry (MS)
- NMR spectral verification
- Microbial limit and heavy metal analysis
Suppliers adhering to ISO 9001 and GMP standards ensure product reliability and compliance with international research chemical regulations.
Transactional: Legal Supply and Safe Procurement OF 11α-Hydroxy Canrenone
1. Regulatory Status
11α-Hydroxy Canrenone is not classified as a controlled substance in most regions but is regulated as a pharmaceutical research compound. Legal procurement requires adherence to chemical handling and import guidelines.
| Region | Regulatory Authority | Use Status |
|---|---|---|
| United States | FDA / DEA | Not controlled; regulated as research-grade steroid intermediate |
| European Union | EMA / REACH | Legal for analytical and pharmaceutical R&D use |
| United Kingdom | MHRA | Permitted for laboratory and industry research |
| Asia-Pacific | National FDA equivalents | Legal for licensed research entities |
2. Procurement Guidelines
To ensure compliance and safety:
- Source only from verified laboratories or chemical suppliers.
- Obtain a COA and MSDS for documentation and traceability.
- Ensure intended use aligns with non-clinical research purposes.
- Follow local import/export control laws for chemical substances.
3. Safe Handling
| Hazard | Precautions |
|---|---|
| May cause mild irritation | Use protective gloves and goggles |
| Avoid inhalation or ingestion | Handle in a ventilated laboratory hood |
| Disposal | Dispose of waste according to local environmental regulations |
11α-Hydroxy Canrenone and Industry Overview ONLINE
1. Market Trends
With rising interest in selective mineralocorticoid receptor modulators (MRMs) and aldosterone blockers, 11α-Hydroxy Canrenone is gaining attention among researchers studying hypertension, renal disorders, and steroid pharmacology.
2. Target Audience
- Pharmaceutical R&D organizations developing new MR antagonists.
- Academic researchers in endocrinology and toxicology.
- Analytical laboratories conducting steroid standardization testing.
- Bulk chemical suppliers specializing in steroid intermediates.
3. SEO Keywords
11α-Hydroxy Canrenone powder • canrenone metabolite • aldosterone antagonist research • mineralocorticoid receptor inhibitor • steroid intermediate supplier • spironolactone derivative • research chemical • analytical reference compound • GMP steroid raw material
Conclusion 11α-Hydroxy Canrenone NEAR ME
11α-Hydroxy Canrenone is a valuable steroidal research compound offering insights into aldosterone receptor mechanisms, metabolic pathways, and pharmaceutical formulation studies.
For compliant access:
- Purchase only from ISO/GMP-certified suppliers.
- Request COA and MSDS documentation for quality verification.
- Ensure use is limited to research, analytical, or educational purposes.
This compound continues to play an integral role in pharmaceutical R&D, endocrine biochemistry, and analytical testing, advancing the understanding of steroid receptor pharmacology and drug development.
