Acquire Phenylboronic Acid from Factory Supply – CAS Number 864759-63-7, CAS Number 98-80-6

Introduction

Phenylboronic Acid, also known as boronic acid, is an important organic compound widely used in chemistry, pharmaceuticals, and materials science. Factory supply searches are common among chemists and industrial buyers seeking high-purity reagents for synthesis, research, or manufacturing.

This article explores its chemical properties, applications, safety, and legal ways to obtain it from reputable suppliers, while addressing the commercial and transactional aspects legally.

Phenylboronic Acid / Boronic Acid: Uses, Benefits, and Legal Factory Supply

Informational: What is Phenylboronic Acid?

Phenylboronic Acid is an aromatic boronic acid with the formula C6H5B(OH)2. It is commonly used in organic synthesis due to its ability to form reversible covalent bonds with diols and other functional groups.

Key Facts:

• Appearance: White crystalline powder
• Solubility: Soluble in organic solvents like ethanol and DMSO; partially soluble in water
• Reactivity: Forms boronate esters with alcohols, useful in Suzuki-Miyaura cross-coupling reactions
• Purity: High-purity (?99%) is essential for chemical synthesis

Applications:

1. Pharmaceuticals: Intermediate for drug synthesis, including antibiotics and anticancer agents
2. Materials Science: Used in polymers, sensors, and functional materials
3. Chemical Research: Essential reagent in Suzuki coupling and other organic transformations

Navigational: Legal and Safe Access

Phenylboronic Acid is legal to purchase and handle in most countries for laboratory, industrial, or educational purposes. However, safety and proper sourcing are important.

Legal Pathways:

1. Licensed Chemical Suppliers
   • Purchase through GMP-certified chemical manufacturers or distributors.
   • Ensure proper documentation and compliance with local chemical regulations.
2. Factory Supply Channels
   • Bulk supply directly from chemical factories for industrial or laboratory use.
   • Verify certificates of analysis (COA) to guarantee purity and authenticity.
3. Educational and Research Institutions
   • Universities and research labs can procure it for experiments under standard chemical safety guidelines.

Tip: Always confirm the supplier’s license and COA before purchase to ensure compliance and quality.

Commercial: Advantages and Disadvantages

Advantages of Phenylboronic Acid

• High Reactivity: Ideal for organic synthesis and pharmaceutical intermediates
• Versatile Applications: Useful in research, materials science, and drug development
• Stable Compound: Easy to store under recommended conditions
• Bulk Availability: Factory supply allows cost-effective procurement for industrial use

Disadvantages / Risks

• Handling Precautions: Irritant to skin, eyes, and respiratory tract if not handled properly
• Storage Requirements: Sensitive to moisture and heat; requires sealed containers
• Regulatory Compliance: Must follow chemical handling and transport regulations
• Quality Variation: Impure products can affect reaction yields and reproducibility

Key Insight: When sourced responsibly from reputable factories, Phenylboronic Acid is safe, effective, and highly versatile.

Transactional: How to Purchase Safely and Legally

Step 1: Verify Supplier Credentials

• Ensure suppliers are GMP-certified or ISO-certified.
• Request COA and Material Safety Data Sheets (MSDS) for verification.

Step 2: Determine Quantity and Purity Needs

• Laboratory research may require grams or kilograms; industrial applications may need bulk tons.
• Specify purity ?99% for sensitive reactions.

Step 3: Follow Safety Guidelines

• Use gloves, lab coat, and eye protection while handling
• Store in dry, cool, and ventilated environments
• Follow local chemical regulations for transport and disposal

Step 4: Legal Purchase Channels

• Purchase from factory-direct suppliers or verified distributors
• Avoid unverified online vendors to ensure legal compliance and product quality

Safe CTA Examples:

• “Contact certified chemical suppliers for bulk Phenylboronic Acid.”
• “Request COA from factory suppliers for guaranteed purity.”
• “Learn how to legally procure boronic acids for research and industrial applications.”

Comparison Table: Bulk Factory Supply vs. Small-Scale Suppliers

FAQs About Phenylboronic Acid

Q1: Is Phenylboronic Acid safe to handle?
Yes, with proper PPE and chemical handling procedures. Avoid inhalation, ingestion, or skin contact.

Q2: Can I buy it online?
Yes, but ensure the supplier is licensed, provides COA, and follows legal chemical regulations.

Q3: What are common uses in research?
Suzuki-Miyaura cross-coupling reactions, sensor development, polymer synthesis, and drug intermediates.

Q4: How should it be stored?
Store in sealed containers, in a dry, cool, and ventilated area away from moisture and heat.

Conclusion

Phenylboronic Acid / Boronic Acid is a versatile, high-value chemical widely used in research, pharmaceutical development, and materials science. Factory supply channels ensure high-purity, cost-effective, and legally compliant access for industrial and laboratory use.

By sourcing from verified suppliers, following safety protocols, and understanding its applications and risks, professionals can maximize its benefits safely and legally.

?  Integrated:

• Phenylboronic Acid factory supply
• Boronic Acid bulk purchase
• Uses of Phenylboronic Acid
• Legal chemical suppliers
• High-purity Boronic Acid

Factory supply Phenylboronic/ Boronic acid CAS NO. 864759-63-7, CAS NO. 98-80-6 from Factory Supply. Phenylboronic Acid, also known as Benzeneboronic Acid, abbreviated as PhB(OH)? where Ph represents the phenyl group C?H?-, is a boronic acid with a phenyl substituent and two hydroxyl groups attached to a boron atom. This compound appears as a white powder and is extensively utilized in organic synthesis. Boronic acids are considered mild Lewis acids, known for their stability and ease of handling, which makes them crucial in organic chemistry. Purchase Phenylboronic Acid – CAS Number 864759-63-7, CAS Number 98-80-6.

Phenylboronic Acid exhibits solubility in most polar organic solvents, though it is less soluble in hexanes and carbon tetrachloride. This molecule is characterized by its planar structure with idealized C?v molecular symmetry. The boron atom within the compound is sp²-hybridized and contains an empty p-orbital. Orthorhombic crystal formations use hydrogen bonding to create dimeric units consisting of two molecules each. These dimeric units further extend into a network through hydrogen bonding. The molecule maintains a planar conformation with slight bending around the C-B bond, measuring 6.6° and 21.4° for the two PhB(OH)? molecules. Purchase Phenylboronic Acid – CAS Number 864759-63-7, CAS Number 98-80-6.

Synthesis of Phenylboronic Acid

Phenylboronic Acid can be synthesized through various methods. A commonly employed technique involves the reaction of phenylmagnesium bromide with trimethyl borate to form the ester PhB(OMe)?, which is subsequently hydrolyzed to yield the desired product. Alternative synthesis routes may involve electrophilic borates to capture phenylmethyl intermediates derived from phenyl halides or directed ortho-metalation. Additionally, phenylsilanes and phenylstannanes can transmetalate with BBr?, followed by hydrolysis to produce phenylboronic acid. Another approach includes coupling aryl halides or triflates with diboronyl reagents using transition metal catalysts, and aromatic C-H functionalization can also be performed using transition metal catalysts. Purchase Phenylboronic Acid – CAS Number 864759-63-7, CAS Number 98-80-6.

Reactions Involving Phenylboronic Acid

The dehydration of boronic acids leads to the formation of boroxines, which are trimeric anhydrides of phenylboronic acid. This dehydration reaction is typically driven by thermal energy or occasionally by a dehydration agent. Purchase Phenylboronic Acid – CAS Number 864759-63-7, CAS Number 98-80-6.

Synthesis of Triphenyl Boroxine

Phenylboronic Acid is actively involved in various cross-coupling reactions, where it acts as a source of phenyl groups. A notable example is the Suzuki reaction, where phenylboronic acid and vinyl halides are coupled in the presence of a Pd(0) catalyst and base to produce phenyl alkenes. This method has been generalized for producing biaryls by coupling phenylboronic acid with aryl halides. Purchase Phenylboronic Acid – CAS Number 864759-63-7, CAS Number 98-80-6.

Phenylboronic Acid is frequently used in C-C bond-forming processes as a reagent. Alpha-amino acids can be synthesized through the uncatalyzed reaction involving alpha-ketoacids, amines, and phenylboronic acid. Additionally, Heck-type cross-coupling of phenylboronic acid with alkenes and alkynes has been demonstrated. Purchase Phenylboronic Acid – CAS Number 864759-63-7.

Phenylboronic Acid can also be utilized to generate aryl azides and nitroaromatics. Furthermore, phenylboronic acid can be regioselectively halodeboronated using aqueous bromine, chlorine, or iodine. Purchase Phenylboronic Acid – CAS Number 864759-63-7, CAS Number 98-80-6.

Boronic Esters

Boronic esters are formed through the condensation of boronic acids with alcohols. This reaction involves the substitution of the hydroxyl group with alkoxy or aryloxy groups. The transformation is typically driven to completion using a Dean-Stark apparatus or a dehydration agent to remove water.

As an extension of this reactivity, PhB(OH)? can be employed as a protecting group for diols and diamines. This reactivity underpins the use of phenylboronic acid in various applications such as carbohydrate receptors and sensors, antimicrobial agents, enzyme inhibitors, neutron capture therapy for cancer treatment, transmembrane transport, as well as bioconjugation, and protein and cell surface labeling.

Quick Details

• Classification: Pharmaceutical Intermediates
• CAS Number: 98-80-6
• Name: Phenylboronic Acid
• Molecular Formula: C?H?BO?
• Melting Point: 217-220°C
• Boiling Point: 265.9°C at 760 mmHg
• Refractive Index: 1.534
• Flash Point: 114.6°C
• Purity: 98%
• EINECS Number: 202-701-9
• Appearance: White powder

Quality Assurance

• Appearance: White crystalline powder – conforms
• Assay (HPLC): 99.0% minimum – 99.7779%

Available Sources

• Phenylboronic Acid 95, CAS Number 98-80-6 – Sigma-Aldrich
• Benzeneboronic Acid, 98+% – Alfa Aesar
• Phenylboronic Acid | CAS 98-80-6 – SCBT
• Phenylboronic Acid (contains varying amounts of Anhydride) – ECHEMI
• Factory Supply Phenylboronic/Boronic Acid – CAS Number 864759-63-7, CAS Number 98-80-6

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