Flunitrazepam Rohypnol 1mg
Buy Flunitrazepam Online – Rohypnol 1mg
Flunitrazepam Rohypnol 1mg, commonly known as Rohypnol, belongs to the benzodiazepine family of drugs, primarily used to treat severe insomnia and as an anesthetic aid. Similar to other hypnotics, it is recommended for short-term use or in cases of chronic sleep disorders. Patented in 1962 and introduced for medical use in 1974, Flunitrazepam is infamously recognized by its street names, “roofies” or “floonies,” and is often associated with its illicit use as a date-rape drug.
Uses of Rohypnol 1 mg Tablet
In countries where Flunitrazepam is legally prescribed, it is utilized to treat severe sleep disorders and occasionally as a pre-anesthetic medication. It has also been used in combination with ketamine to minimize the negative side effects associated with anesthesia, such as confusion during awakening, changes in heart rate, and blood pressure irregularities.
Adverse Effects of Flunitrazepam
Flunitrazepam can cause both physical and psychological dependence and may lead to significant side effects such as:
- Reduced sleep quality, leading to drowsiness
- Overdose, resulting in profound sedation
- Impaired balance and speech
- Respiratory depression, coma, or death in extreme cases
Due to these risks, it has been implicated in cases of suicide and is considered dangerous if used in late pregnancy, as it may cause hypotonia (reduced muscle tone) in the fetus.
Dependence and Withdrawal
Flunitrazepam, like other benzodiazepines, can lead to drug dependence. Discontinuing the drug may result in withdrawal symptoms such as seizures, psychosis, anxiety, and insomnia. Rebound insomnia, worse than the initial sleep issues, often occurs after stopping even short-term use.
Paradoxical Effects
In some cases, Flunitrazepam can cause paradoxical reactions, including:
- Heightened anxiety or aggression
- Confusion and disinhibition
- Loss of impulse control
- Talkativeness and violent behavior
- Convulsions or seizures
These effects can sometimes lead to criminal behavior.
Hypotonia and Use in Pregnancy
Flunitrazepam, being lipophilic, crosses the placental barrier rapidly, which can result in hypotonia (floppy baby syndrome) when used in large doses during late pregnancy.
Cognitive and Motor Impairment
Flunitrazepam negatively impacts cognitive functions, leading to confusion, memory loss, and anterograde amnesia (inability to form new memories). These effects can persist into the next day, manifesting as a hangover-like state. The drug also impairs psychomotor functions, increasing the risk of falls and fractures, especially when combined with alcohol. Tolerance to these impairments develops slowly, and alcohol amplifies these risks.
Other side effects include:
- Slurred speech
- Digestive disturbances, lasting 12 or more hours
- Vomiting
- Respiratory depression at higher doses
Special Precautions
Particular care should be taken when using benzodiazepines like Flunitrazepam, especially in elderly patients, pregnant women, children, individuals with alcohol or drug dependency, and those with underlying psychological conditions. The drug significantly impairs driving abilities, leading to an increased risk of traffic accidents. This risk is higher with Flunitrazepam compared to other hypnotics.
Drug Interactions
Combining Flunitrazepam with alcohol or CNS depressants (e.g., opioids) can result in dangerous toxicity and may lead to death.
Benzodiazepine Overdose
Overdosing on Flunitrazepam can cause severe sedation, balance, and speech issues, and in more extreme cases, respiratory depression, coma, or death. The risk of overdose is heightened when combined with alcohol or opioids. Flumazenil, a GABAA receptor antagonist, can be used as a treatment for benzodiazepine overdose.
Detection of Flunitrazepam
As of 2016, blood tests can detect Flunitrazepam at concentrations as low as 4 nanograms per milliliter, with the drug’s half-life ranging from 4 to 12 hours. Urine tests can identify metabolites for 60 hours to 28 days, depending on the dosage and method of analysis. Hair and saliva can also be tested, with hair samples being useful for determining long-term drug use and saliva for workplace drug tests.
In cases of drug intoxication or medicolegal investigations, blood or plasma tests can confirm Flunitrazepam consumption. The 7-amino flunitrazepam metabolite is particularly useful in verifying intake.
Pharmacology of Flunitrazepam
Flunitrazepam enhances the effects of GABA, an inhibitory neurotransmitter, by binding to GABA receptors. Approximately 80% of the drug is absorbed orally, but in suppository form, bioavailability is closer to 50%. It has a long half-life of 18 to 26 hours, meaning its effects may last throughout the following day due to the production of active metabolites, which further extend its duration compared to other benzodiazepines.
Flunitrazepam is metabolized in the liver through oxidative pathways, primarily involving the enzyme CYP3A4.
Flunitrazepam is a powerful drug with both therapeutic and high-risk uses, so it’s essential to take all necessary precautions and understand the potential side effects and dangers before use.
