3-Butyn-1-ol Solution: Properties, Applications, and Research Significance
Introduction
3-Butyn-1-ol is an alkynyl alcohol commonly used in organic synthesis, industrial applications, and chemical research. Its solution form is convenient for laboratory handling, dosing, and reaction workups.
The compound is primarily used for:
- Synthesis of fine chemicals and intermediates
- Pharmaceutical research and experimental chemistry
- Industrial applications in coatings, resins, and specialty chemicals
3-Butyn-1-ol is handled legally in licensed laboratories and industrial facilities, with strict adherence to safety and regulatory guidelines.
Informational: Chemical Identity and Properties
| Property | Details |
|---|---|
| Chemical Name | 3-Butyn-1-ol |
| Molecular Formula | C₄H₆O |
| Molecular Weight | 70.09 g/mol |
| CAS Number | 107-19-7 |
| Chemical Class | Alkynyl alcohol |
| Appearance | Colorless liquid (solution may vary in concentration) |
| Boiling Point | 145–147 °C |
| Melting Point | -27 °C |
| Solubility | Miscible with water and most organic solvents |
| Storage Conditions | Store in tightly sealed containers, in a cool, ventilated area, away from heat and oxidizing agents |
Key Features
- Terminal alkyne group: Provides reactivity for substitution, addition, and coupling reactions.
- Hydroxyl group: Facilitates hydrogen bonding, solubility, and chemical modifications.
- Solution form: Reduces handling risks, ensures precise dosing, and simplifies integration into reactions.
Navigational: Applications in Research and Industry
Laboratory and Industrial Uses
- Organic Synthesis – Intermediate in the preparation of pharmaceuticals, agrochemicals, and fine chemicals.
- Polymer and Resin Chemistry – Used in the synthesis of functionalized polymers and specialty coatings.
- Pharmaceutical Research – Employed in medicinal chemistry to generate derivatives for biological testing.
- Analytical Chemistry – Reference material for reaction studies and chromatographic calibration.
Reaction Examples
| Reaction Type | Purpose | Key Features |
|---|---|---|
| Sonogashira coupling | Forms carbon–carbon bonds with aryl/alkyl halides | Efficient cross-coupling for complex molecules |
| Oxidation | Converts alcohol to aldehydes/ketones | Useful in synthesis of intermediates |
| Esterification | Produces esters for fine chemicals | Provides lipophilic derivatives |
| Hydrogenation | Reduces alkyne to alkene/alcohol | Selective modification of alkyne functionality |
Commercial: Legal Supply and Laboratory Use
3-Butyn-1-ol solution is available through licensed chemical suppliers for research and industrial purposes.
| Supplier Type | Regulatory Requirement | Permitted Use |
|---|---|---|
| ISO-certified chemical suppliers | Standard chemical purchase agreement | Laboratory and industrial research |
| Academic and research institutions | Institutional safety approval | Organic synthesis and teaching labs |
| Industrial research labs | Chemical handling permit | Production of polymers, resins, and specialty chemicals |
Note: Handling and transport require adherence to local, national, and international chemical regulations, including proper labeling and Material Safety Data Sheet (MSDS) compliance.
Safety Profile and Handling
3-Butyn-1-ol is flammable and irritant, requiring appropriate safety precautions.
| Hazard Classification (GHS) | Symbol | Precautionary Measures |
|---|---|---|
| Flammable liquid | 🔥 | Keep away from open flames, sparks, and heat sources |
| Skin/eye irritant | ⚠️ | Use gloves, goggles, and lab coat |
| Respiratory hazard | ⚠️ | Work in ventilated fume hoods |
| Environmental hazard | ☣️ | Avoid release into water systems; follow disposal protocols |
Best Practices:
- Store in a cool, ventilated, and tightly sealed container
- Use in fume hoods or well-ventilated laboratories
- Avoid incompatible chemicals, such as strong oxidizers
- Follow MSDS and institutional safety guidelines
Transactional: Regulatory Status
3-Butyn-1-ol is generally available as a legal laboratory and industrial chemical, but must be handled according to chemical safety regulations.
| Region / Country | Legal Classification | Regulatory Reference |
|---|---|---|
| United States | Laboratory chemical | OSHA, EPA chemical regulations |
| European Union | Research chemical | REACH compliance, CLP labeling |
| United Kingdom | Industrial and laboratory chemical | HSE chemical safety regulations |
| Canada | Controlled under chemical handling standards | Health Canada chemical safety protocols |
| Australia | Schedule 5 chemical | TGA and Safe Work Australia guidelines |
✅ Licensed laboratories and industrial facilities may legally purchase and use 3-Butyn-1-ol solution for research, synthesis, and industrial applications.
Comparative Table: 3-Butyn-1-ol vs Other Alkynyl Alcohols
| Compound | Chemical Class | Primary Use | Boiling Point (°C) | Legal Status |
|---|---|---|---|---|
| 3-Butyn-1-ol | Terminal alkynyl alcohol | Organic synthesis, polymers | 145–147 | Legal, research/industrial |
| 2-Butyn-1-ol | Terminal alkynyl alcohol | Fine chemicals, synthesis | 120–122 | Legal, research/industrial |
| Propargyl alcohol | Terminal alkynyl alcohol | Pharmaceuticals, intermediates | 97 | Legal, controlled use in labs |
| 4-Pentyn-1-ol | Terminal alkynyl alcohol | Specialty chemical synthesis | 150–152 | Legal, research/industrial |
This table helps researchers, chemists, and industrial professionals compare reactivity, applications, and handling requirements.
Research and Industrial Significance
3-Butyn-1-ol is crucial for:
- Developing advanced organic intermediates for pharmaceuticals and fine chemicals
- Polymer functionalization for specialty coatings and resins
- Analytical and calibration purposes in chemical research
- Education in organic chemistry as a model terminal alkyne alcohol
Its solution form improves handling safety and reaction accuracy, making it highly valuable in laboratory and industrial applications.
Conclusion
3-Butyn-1-ol solution is a versatile alkynyl alcohol with applications across organic synthesis, polymer chemistry, pharmaceutical research, and analytical laboratories.
It must be handled in licensed facilities, following chemical safety guidelines, PPE protocols, and regulatory compliance. For chemists, researchers, and industrial professionals, it provides a powerful tool for producing fine chemicals, intermediates, and specialty compounds.
Keywords
3-Butyn-1-ol solution • alkynyl alcohol research • organic synthesis reagent • terminal alkyne chemical • laboratory chemical solution • industrial chemical intermediate • polymer and resin chemistry • fine chemical synthesis
Factory supplies 3-Butyn-1-ol solution/ CAS:927-74-2/ wholesale price at competitive wholesale prices directly from the factory. 3-Butyn-1-ol, also known as 2-Methylbut-3-yn-2-ol, is an organic compound with the formula HC≡CCH₂CH₂OH. It is a colorless liquid and classified as an alkynyl alcohol.
Production and Applications: 3-Butyn-1-ol is typically synthesized through the condensation of acetylene and acetone, a reaction that can be facilitated by bases or Lewis acid catalysts. Industrially, it is used as a precursor for the production of terpenes and terpenoids. Additionally, it serves as a monoprotected form of acetylene, which can be arylated and then deprotected for various chemical processes.
Chemical Reactions: An example of its application is in the reaction with aryl halides, where the acetone is removed with a base: HC≡C(OH)Me2+ArX+base→ArC≡C(OH)Me2+[Hbase]XHC≡C(OH)Me₂ + ArX + \text{base} \rightarrow ArC≡C(OH)Me₂ + [H\text{base}]X ArC≡C(OH)Me2→ArC≡H+OCMe2ArC≡C(OH)Me₂ \rightarrow ArC≡H + OCMe₂
