Bradykinin Powder: Structure, Research Applications, and Legal Procurement
Introduction
Bradykinin is a naturally occurring peptide that plays a critical role in vasodilation, blood pressure regulation, inflammation, and pain signaling.
Bradykinin Powder is primarily used in laboratory research, including cardiovascular studies, inflammatory pathway analysis, and pharmaceutical R&D. While it is biologically active, it is not approved for direct clinical use outside strictly regulated environments.
This article explores chemical properties, physiological relevance, research applications, quality standards, and safe procurement, ensuring compliance and proper use.
Informational: Chemical Identity and Properties
| Parameter | Specification |
|---|---|
| Chemical Name | Bradykinin |
| Synonyms | BK; Bradykinin Peptide; Arg–Pro–Pro–Gly–Phe–Ser–Pro–Phe–Arg |
| CAS Number | 58-31-1 |
| Molecular Formula | C50H73N15O11 |
| Molecular Weight | 1060.23 g/mol |
| Peptide Sequence | Arg–Pro–Pro–Gly–Phe–Ser–Pro–Phe–Arg |
| Appearance | White to off-white lyophilized powder |
| Solubility | Soluble in water; insoluble in non-polar solvents |
| Purity | ≥ 98% (HPLC) |
| Storage Conditions | –20 °C, desiccated, protected from light |
| Documentation | Certificate of Analysis (COA), Safety Data Sheet (SDS) |
Bradykinin is a nonapeptide, meaning it consists of 9 amino acids. It is highly water-soluble and sensitive to enzymatic degradation, which must be considered during experimental design.
Biological Function and Mechanism
Bradykinin is part of the kinin–kallikrein system, regulating vascular tone and inflammatory responses:
- Vasodilation: Stimulates nitric oxide (NO) production in endothelial cells, leading to vessel relaxation.
- Inflammation: Promotes vascular permeability and recruitment of immune cells.
- Pain Signaling: Activates B1 and B2 receptors, mediating nociceptive pathways.
- Blood Pressure Regulation: Works in opposition to vasoconstrictors like angiotensin II.
These physiological roles make Bradykinin a critical tool for cardiovascular, renal, and inflammatory research, as well as pharmacological testing of receptor antagonists.
Navigational: Research Applications
1. Cardiovascular and Renal Studies
- Used to study vasodilation, hypotension, and endothelial function.
- Assists in evaluating ACE inhibitors and other antihypertensive drugs.
- Supports research on kidney function and electrolyte balance.
2. Inflammation and Pain Pathway Analysis
- Models acute and chronic inflammatory conditions in vitro and in vivo.
- Helps investigate pain mediators and analgesic drug mechanisms.
- Essential for studying immune cell recruitment and vascular leakage.
3. Pharmaceutical and Biotech Research
- Used as a reference peptide in receptor binding assays.
- Supports drug discovery for B1 and B2 receptor modulators.
- Serves in peptide stability and pharmacokinetic studies.
4. Educational and Analytical Use
- Demonstrates peptide signaling mechanisms in laboratory teaching.
- Functions as a calibration standard for HPLC and LC-MS analyses.
Commercial: Quality Standards and Supplier Considerations
1. Available Grades
| Grade | Purity | Application |
|---|---|---|
| Analytical/Research Grade | ≥ 98% | Laboratory assays, receptor studies, and pharmacology research |
| Peptide Synthesis Grade | ≥ 95% | Custom synthesis, receptor binding, and structural studies |
| Bulk/Industrial Grade | 90–95% | High-volume R&D or method validation |
2. Packaging and Documentation
- Lyophilized in vials ranging from 1 mg to 50 mg.
- Nitrogen-flushed, moisture-proof packaging recommended.
- COA and SDS provided to verify purity, identity, and stability.
3. Quality Assurance
- Verified using HPLC, LC-MS, and peptide sequencing.
- Free from residual solvents or contaminants.
- Suppliers typically provide ISO or GMP certification for research and industrial applications.
Transactional: Legal Supply and Compliance
Bradykinin Powder is a research-grade peptide, legally sold for laboratory and pharmaceutical research purposes. It is not intended for human consumption.
Regulatory Overview
| Region | Regulatory Authority | Requirements |
|---|---|---|
| United States | FDA / DEA | Research use only; must comply with chemical handling regulations |
| European Union | EMA / REACH | Requires laboratory usage documentation and safe handling procedures |
| United Kingdom | MHRA | Permitted under research licenses; GMP documentation required for pharma R&D |
| Asia-Pacific | Local ministries | Peptide handling requires COA, SDS, and institutional approval |
Safe Procurement Guidelines
- Purchase only from certified peptide suppliers with documentation.
- Verify COA and SDS for purity, sequence accuracy, and moisture content.
- Store and handle according to peptide safety standards (–20 °C, desiccated).
- Keep records for compliance with institutional and regulatory policies.
Handling and Safety
| Hazard | Precaution |
|---|---|
| Bioactive Peptide | Use gloves, lab coat, and eye protection; avoid inhalation or ingestion |
| Storage | –20 °C, desiccated, light-protected |
| Reconstitution | Use sterile, nuclease-free water; avoid repeated freeze-thaw cycles |
| Disposal | Treat as bioactive chemical waste; follow institutional protocols |
| Spill Management | Use absorbent materials, ventilate, and dispose according to local regulations |
Market and Research Outlook
Bradykinin Powder remains a critical research tool in:
- Cardiovascular pharmacology
- Inflammatory and pain pathway research
- Drug discovery targeting B1/B2 receptors
The growing demand for high-purity peptides in academic, pharmaceutical, and biotech research ensures continued market relevance. Suppliers providing traceable, certified Bradykinin Powder are preferred for reproducible and compliant research.
Bradykinin Powder Conclusion
Bradykinin Powder is an essential tool for cardiovascular, inflammatory, and pharmacological research. With high purity, stability, and verified documentation, it supports receptor studies, drug development, and analytical assays.
By sourcing from certified, compliant suppliers, researchers can ensure legal, safe, and effective use, making Bradykinin Powder a cornerstone peptide in modern biomedical and pharmaceutical research.
Bradykinin Powder Keywords
bradykinin powder • bradykinin peptide • B1 B2 receptor research • peptide hormone research • analytical grade bradykinin • cardiovascular research peptide • inflammation signaling peptide • laboratory reference bradykinin • HPLC standard bradykinin • pharmaceutical research peptide
Biological Function and Applications
Bradykinin is a physiologically active peptide involved in several critical processes:
- Vascular Effects: It promotes the dilation of arterioles by inducing the release of prostacyclin, nitric oxide, and endothelium-derived hyperpolarizing factor, while constricting veins through prostaglandin F2, which leads to increased capillary leakage.
- Pain and Inflammation: Bradykinin stimulates pain receptors and contributes to inflammation and edema resulting from trauma or injury.
- Heart Recovery: It aids in post-ischemic recovery of the heart via a nitric oxide-dependent mechanism.
- Smooth Muscle Contraction: It plays a role in inducing smooth muscle contraction and vasodilation.
Pharmacological Interactions
Bradykinin levels can be increased by angiotensin-converting enzyme (ACE) inhibitors, which prevent its degradation. This enhancement of bradykinin’s effects contributes to its blood pressure-lowering impact. ACE inhibitors are FDA-approved for treating hypertension and heart failure.
Related Products
- Bradykinin (CAS No. 58-82-2) – Research Chem Lab
- Bradykinin – R&D Systems
- Bradykinin – Calbiochem
- Bradykinin | VWR
- Bradykinin Supplier – Arctom Products
General Description
Bradykinin induces nitric oxide release and has various physiological functions, including stimulating pain receptors, inhibiting cAMP accumulation, and inducing smooth muscle contraction. It is also involved in the edema response following trauma and improves cardiac recovery post-ischemia through a nitric oxide-dependent mechanism.
Contact Information
For further details, quotes, or to place an order, please get in touch with us. We are dedicated to providing high-quality Bradykinin powder and excellent service.
