Buy Antiepileptic Gabapentine powder/ CAS 60142-96-3 / factory supply
Gabapentin Powder: Pharmaceutical Profile, Clinical Applications, and Research Insights
Introduction
Gabapentin (CAS No. 60142-96-3) is a widely used antiepileptic and neuropathic pain medication, structurally related to the neurotransmitter GABA (gamma-aminobutyric acid). Originally developed to treat epilepsy, gabapentin is now also prescribed for neuropathic pain, restless leg syndrome, and anxiety disorders.
Gabapentin powder refers to the active pharmaceutical ingredient (API) used in drug formulation, pharmaceutical research, and analytical studies. While gabapentin is legally available by prescription, research and licensed pharmaceutical use of the powder is fully legal under regulatory compliance.
Informational: Chemical Identity and Properties
| Property | Details |
|---|---|
| Chemical Name | 1-(Aminomethyl)cyclohexaneacetic acid |
| Common Names | Gabapentin, Neurontin (brand) |
| Chemical Formula | C₉H₁₇NO₂ |
| Molecular Weight | 171.24 g/mol |
| CAS Number | 60142-96-3 |
| Chemical Class | Gamma-aminobutyric acid analog |
| Appearance | White crystalline powder |
| Melting Point | 195–200 °C |
| Solubility | Soluble in water and methanol; slightly soluble in ethanol |
| Storage Conditions | Store in airtight containers, protected from light and moisture, 2–8 °C |
Mechanism of Action
Gabapentin binds to the α₂δ subunit of voltage-gated calcium channels in the central nervous system. This reduces calcium influx, decreasing excitatory neurotransmitter release, and leading to:
- Anticonvulsant effects (reduction of seizures)
- Neuropathic pain relief
- Sedative and anxiolytic effects in some patients
Unlike traditional GABA analogs, gabapentin does not directly activate GABA receptors, making it well-tolerated and safer in combination therapies.
Navigational: Clinical and Research Applications
Gabapentin powder is widely used in pharmaceutical research, formulation development, and clinical studies.
Clinical Uses
| Indication | Role of Gabapentin | Dosage Form |
|---|---|---|
| Epilepsy | Adjunct therapy for partial seizures | Tablets, capsules, oral solution |
| Neuropathic Pain | Reduces nerve pain | Capsules, tablets |
| Restless Leg Syndrome | Symptom management | Capsules |
| Anxiety Disorders | Off-label use | Oral formulations |
Research and Laboratory Use
Licensed laboratories use gabapentin powder for:
- Analytical standard preparation for HPLC, LC-MS/MS, and GC-MS studies
- Formulation development in generic or novel dosage forms
- Pharmacokinetic and bioavailability studies
- Academic teaching in pharmaceutical chemistry and medicinal chemistry courses
Commercial: Legal and Licensed Supply
Gabapentin powder is available through licensed pharmaceutical manufacturers and ISO-certified suppliers.
| Supplier Type | Regulatory Requirement | Permitted Use |
|---|---|---|
| Pharmaceutical manufacturers | GMP compliance, prescription drug license | Production of tablets, capsules, oral solution |
| ISO-certified research suppliers | Controlled chemical handling license | Analytical calibration, pharmacokinetic research |
| Academic institutions | Institutional ethics approval | Educational and pharmacological studies |
| Compounding pharmacies | State/federal licensing | Customized patient formulations |
⚠️ Unlicensed sale or possession of gabapentin powder for human consumption is illegal. All handling should comply with local and international pharmaceutical regulations.
Safety Profile and Handling
Gabapentin is generally considered well-tolerated, but proper laboratory handling is essential to prevent contamination or degradation.
| Hazard Classification (GHS) | Symbol | Precautionary Measures |
|---|---|---|
| Low toxicity | ⚠️ | Avoid inhalation and ingestion of powder |
| Eye/Skin irritation | ⚠️ | Use gloves, goggles, and protective clothing |
| Environmental hazard | ☣️ | Dispose via licensed pharmaceutical waste channels |
Laboratory Best Practices:
- Use in a clean, ventilated workspace
- Store in airtight, light-protected containers at 2–8 °C
- Maintain accurate documentation and quality control records
Transactional: Regulatory Status
Gabapentin is a prescription-only drug in most countries. Its powder form is used legally for pharmaceutical and research purposes under licensing.
| Region / Country | Legal Classification | Regulatory Reference |
|---|---|---|
| United States | Schedule V controlled substance in some states | FDA, DEA |
| European Union | Prescription-only medication | EMA guidelines |
| Canada | Prescription-only drug | Health Canada |
| United Kingdom | Prescription-only medication | MHRA regulations |
| Australia | Schedule 4 prescription medicine | TGA |
✅ Only licensed facilities may legally handle gabapentin powder for research, formulation, or analytical purposes.
Comparative Table: Gabapentin vs Pregabalin
| Drug | Chemical Class | Mechanism | Clinical Use | Half-Life |
|---|---|---|---|---|
| Gabapentin | GABA analog | α₂δ calcium channel subunit | Epilepsy, neuropathic pain | 5–7 h |
| Pregabalin | GABA analog | α₂δ calcium channel subunit | Neuropathic pain, fibromyalgia | 6.3 h |
This comparison helps researchers and clinicians choose appropriate analogs for formulation and pharmacology studies.
Research Insights
Gabapentin powder supports:
- Bioavailability studies for new oral formulations
- Analytical method validation in QC labs
- Structure-activity studies in medicinal chemistry
- Toxicology research for safety assessment
These applications advance pharmaceutical development and support evidence-based medical practice.
Conclusion
Gabapentin powder is a key antiepileptic and neuropathic pain research compound, essential for pharmaceutical development, analytical calibration, and academic studies.
With proper legal licensing, handling protocols, and safety measures, gabapentin powder provides a versatile tool for research, formulation, and education while remaining fully compliant with national and international regulations.
Keywords
Gabapentin powder • gabapentin API • antiepileptic research compound • neuropathic pain pharmaceutical research • gabapentin analytical standard • prescription-only GABA analog • gabapentin formulation studies • licensed pharmaceutical powder
Purchase Antiepileptic Gabapentin Powder / CAS 60142-96-3
Buy Antiepileptic Gabapentine powder/ CAS 60142-96-3 / factory supply. Acquire high-quality Antiepileptic Gabapentin powder through our factory supply. Gabapentin, known commercially as Neurontin among other names, is an anticonvulsant medication primarily used to manage partial seizures and neuropathic pain. It is considered a first-line treatment for neuropathic pain associated with diabetic neuropathy, postherpetic neuralgia, and central pain. Gabapentin is moderately effective, with about 30-40% of patients experiencing significant relief from diabetic neuropathy or postherpetic neuralgia.
Buy Antiepileptic Gabapentin Powder
Gabapentin is typically well-tolerated, though common side effects include sleepiness and dizziness. Serious side effects may include an increased risk of suicide, respiratory depression, and allergic reactions. Lower doses are recommended for individuals with kidney disease. Gabapentin works by decreasing activity in certain calcium channels.
Gabapentin Powder Suppliers
Gabapentin was approved for use in 1993 and has been available as a generic medication in the U.S. since 2004. In 2019, it was among the top ten most prescribed medications in the U.S., with over 47 million prescriptions. During the 1990s, its manufacturer, Parke-Davis (a Pfizer subsidiary), faced legal issues for using improper methods to promote gabapentin for unapproved uses, resulting in significant settlements.
Buy Antiepileptic Gabapentin Powder / CAS 60142-96-3
We provide high-quality pharmaceutical-grade Gabapentin powder suitable for various applications, including pharmaceutical intermediates. Our products are available for purchase at competitive wholesale prices.
For further details or to place an order, visit our online store or contact us directly for the best rates on Gabapentin powder and other related products.
Additional Information:
- API Factory Supply: Antiepileptic Gabapentin Powder
- High-Quality Pharmaceutical Grade: Oral AEDs Gabapentin
- Product Price and Suppliers: Check our website for current pricing and suppliers.
Order Gabapentin powder (C9H17NO2) from our trusted sources. Gabapentin is a key raw material for antiepileptic medications, known for its efficacy and reliability. For the best prices and availability, consult our detailed listings or get in touch with our support team.
