BUY 5FMDMB-2201 crystal powder/ CAS 88949-21-2 / online
Introduction
5F-MDMB-2201 is a synthetic cannabinoid that belongs to the indazole-based cannabinoids class. It has been widely discussed in the context of new psychoactive substances (NPS), but its primary value today lies in research, forensic toxicology, and analytical chemistry.
The crystalline form of 5F-MDMB-2201 is primarily used for:
- Forensic reference standards
- Pharmacological research
- Analytical method development for detection of synthetic cannabinoids
Due to its controlled status in many countries, it is only legally handled by licensed laboratories for scientific purposes. BUY 5FMDMB-2201 crystal powder/ CAS 88949-21-2 / online
Informational: Chemical Identity and Properties
| Property | Details |
|---|---|
| Chemical Name | Methyl (S)-2-(1-(5-fluoropentyl)-1H-indazole-3-carboxamido)-3,3-dimethylbutanoate |
| Common Names | 5F-MDMB-2201, 5F-MDMB-PINACA |
| Chemical Formula | C₂₅H₂₈FN₃O₃ |
| Molecular Weight | 459.51 g/mol |
| CAS Number | 1801338-66-9 |
| Chemical Class | Synthetic cannabinoid (indazole-based) |
| Appearance | White crystalline powder |
| Solubility | Soluble in DMSO, methanol, and ethanol; low water solubility |
| Melting Point | 87–90 °C (crystalline) |
| Storage Conditions | Airtight container, protected from light, 2–8 °C |
Mechanism of Action
5F-MDMB-2201 acts as a potent agonist of CB₁ and CB₂ receptors, making it significantly more potent than THC. In research, it is primarily used to study:
- Synthetic cannabinoid receptor binding
- Pharmacological and toxicological profiles
- Analytical differentiation from other NPS
It does not have therapeutic approval; all handling is strictly research-oriented. BUY 5FMDMB-2201 crystal powder/ CAS 88949-21-2 / online
Navigational: Forensic and Research Applications
Synthetic cannabinoids like 5F-MDMB-2201 are commonly encountered in NPS monitoring and forensic laboratories.
Key Applications
- Analytical Reference Material – For calibration in LC-MS/MS, GC-MS, and HPLC studies.
- Metabolic Studies – Identification of metabolites in human and animal biological samples.
- Structure-Activity Research – Understanding synthetic cannabinoid pharmacology and potency.
- Forensic Training – Case studies in modern NPS detection.
Analytical Techniques
| Technique | Purpose | Key Features |
|---|---|---|
| LC-MS/MS | Quantification in biological or seized samples | High sensitivity, detects trace concentrations |
| GC-MS | Structural confirmation | Identifies characteristic indazole and fluoropentyl fragments |
| ¹H/¹³C NMR | Structural elucidation | Confirms chemical identity and purity |
| FT-IR | Functional group analysis | Detects ester, amide, and fluorinated functional groups |
These techniques ensure accurate identification and differentiation from other synthetic cannabinoids.
Commercial: Legal and Licensed Supply
5F-MDMB-2201 is controlled in most jurisdictions, but licensed laboratories can legally obtain it for research, analytical, and educational purposes.
| Supplier Type | Regulatory Requirement | Permitted Use |
|---|---|---|
| ISO-certified reference material suppliers | Controlled substance license | Analytical calibration, toxicology studies |
| Academic research labs | Institutional ethics approval | Receptor studies, metabolism studies |
| Forensic laboratories | DEA/National controlled substance permits | Confirmatory testing and training |
| Pharmaceutical research institutions | Controlled chemical permit | Structure-activity relationship studies |
Important: Legal handling requires chain-of-custody documentation, secure storage, and compliance with local, national, and international laws. BUY 5FMDMB-2201 crystal powder/ CAS 88949-21-2 / online
Safety Profile and Handling
5F-MDMB-2201 is highly potent and can cause neurological or cardiovascular effects if mishandled. Safe laboratory practices are essential.
| Hazard Classification (GHS) | Symbol | Precautionary Measures |
|---|---|---|
| Acute toxicity | ⚠️ | Avoid ingestion or inhalation; PPE required |
| CNS active compound | ⚠️ | Handle in ventilated fume hoods |
| Eye/Skin irritation | ⚠️ | Use gloves, goggles, lab coat |
| Environmental hazard | ☣️ | Dispose through licensed chemical waste channels |
Best Practices:
- Handle in ventilated enclosures
- Store in airtight, light-protected containers at 2–8 °C
- Maintain documentation, labeling, and regulatory compliance
Transactional: Regulatory Status
5F-MDMB-2201 is classified as a controlled synthetic cannabinoid in most countries.
| Region / Country | Legal Classification | Regulatory Reference |
|---|---|---|
| United States | Schedule I analogue / NPS | DEA Controlled Substances Act |
| European Union | Controlled NPS | EMCDDA early warning system |
| United Kingdom | Class B (Psychoactive Substances Act) | Home Office, 2016 |
| Canada | Schedule II analogue | Health Canada Controlled Drugs and Substances Act |
| Australia | Schedule 9 (Poison) | Therapeutic Goods Administration |
✅ Only licensed laboratories may legally acquire 5F-MDMB-2201 crystal powder for research, analytical, or educational purposes. BUY 5FMDMB-2201 crystal powder/ CAS 88949-21-2 / online
Comparative Table: 5F-MDMB-2201 vs Other Synthetic Cannabinoids
| Compound | Chemical Class | Potency | Research Use | Legal Status |
|---|---|---|---|---|
| 5F-MDMB-2201 | Indazole-based cannabinoid | Very High | Analytical & metabolic research | Controlled |
| AB-FUBINACA | Indazole-based cannabinoid | Extremely High | Pharmacology & toxicology | Controlled |
| JWH-018 | Naphthoylindole cannabinoid | Moderate | Historical reference | Controlled |
| CUMYL-PEGACLONE | Gamma-carboline cannabinoid | High | Analytical & receptor studies | Controlled |
This table helps researchers and forensic analysts understand structural, potency, and regulatory differences.
Research and Forensic Significance
5F-MDMB-2201 is crucial for:
- Updating NPS databases for law enforcement and toxicology labs
- Developing analytical methods for LC-MS/MS and GC-MS
- Studying synthetic cannabinoid metabolism and toxicity
- Training forensic professionals on emerging NPS detection
Although recreational use is illegal, it remains an essential research tool for laboratories focused on public health, forensic science, and regulatory compliance.
Conclusion
5F-MDMB-2201 crystal powder is a significant synthetic cannabinoid for research, analytical, and forensic applications. Handling requires licensed, compliant laboratories, proper safety measures, and strict adherence to legal regulations.
For analytical chemists, forensic scientists, and pharmacologists, 5F-MDMB-2201 provides a valuable research compound for understanding synthetic cannabinoid pharmacology, metabolism, and detection methods. BUY 5FMDMB-2201 crystal powder/ CAS 88949-21-2 / online
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