Buy 4F-MDMB-BINACA powder/CAS 2390036-46-9/online
Introduction
4F-MDMB-BINACA is a synthetic cannabinoid of the indazole-based BINACA family. It is primarily studied in forensic toxicology, pharmacology, and analytical chemistry as part of the ongoing research into new psychoactive substances (NPS).
The powder form of 4F-MDMB-BINACA is used mainly for:
- Forensic reference standards
- Analytical method development
- Pharmacological research
- Structure-activity relationship studies
Due to its controlled status in many countries, legal handling is restricted to licensed laboratories for scientific and research purposes.
Informational: Chemical Identity and Properties
| Property | Details |
|---|---|
| Chemical Name | Methyl (S)-2-(1-(4-fluorobutyl)-1H-indazole-3-carboxamido)-3,3-dimethylbutanoate |
| Common Names | 4F-MDMB-BINACA, 4F-MDMB-PINACA |
| Chemical Formula | C₂₅H₂₇FN₃O₃ |
| Molecular Weight | 457.50 g/mol |
| CAS Number | 1801482-24-9 |
| Chemical Class | Synthetic cannabinoid (indazole-based) |
| Appearance | White to off-white crystalline powder |
| Solubility | Soluble in DMSO, methanol, ethanol; low water solubility |
| Melting Point | 88–91 °C |
| Storage Conditions | Store in airtight containers, away from light, at 2–8 °C |
Mechanism of Action
4F-MDMB-BINACA is a highly potent CB₁ and CB₂ receptor agonist, making it significantly stronger than THC. In research, it is used to:
- Study receptor binding and activation
- Examine toxicological profiles
- Develop analytical detection methods for synthetic cannabinoids
It is not approved for human consumption, and all handling is strictly research-oriented.
Navigational: Forensic and Research Applications
Synthetic cannabinoids like 4F-MDMB-BINACA are often encountered in forensic toxicology and NPS monitoring.
Key Applications
- Analytical Reference Material – Used for calibration in LC-MS/MS, GC-MS, and HPLC studies.
- Metabolic Studies – Identification of metabolites in biological samples.
- Pharmacological Research – Investigating potency and receptor binding.
- Forensic Education – Training toxicologists and law enforcement in NPS detection.
Analytical Techniques
| Technique | Purpose | Key Features |
|---|---|---|
| LC-MS/MS | Quantification in biological or seized samples | High sensitivity, detects trace concentrations |
| GC-MS | Structural confirmation | Detects characteristic indazole and fluorobutyl fragments |
| ¹H/¹³C NMR | Structural elucidation | Confirms chemical identity and purity |
| FT-IR | Functional group analysis | Detects ester, amide, and fluorinated functional groups |
These methods ensure accurate identification and differentiation from other synthetic cannabinoids.
Commercial: Legal and Licensed Supply
4F-MDMB-BINACA is controlled in most jurisdictions, but licensed laboratories can legally acquire it for research, analytical, and educational purposes.
| Supplier Type | Regulatory Requirement | Permitted Use |
|---|---|---|
| ISO-certified reference material suppliers | Controlled substance license | Analytical calibration and toxicology studies |
| Academic research labs | Institutional ethics approval | Pharmacology and metabolism studies |
| Forensic laboratories | DEA/National controlled substance permits | Confirmatory testing and training |
| Pharmaceutical research institutions | Controlled chemical permit | Structure-activity research |
Note: Handling requires chain-of-custody documentation, secure storage, and compliance with local, national, and international regulations.
Safety Profile and Handling
4F-MDMB-BINACA is highly potent, and exposure can lead to neurological or cardiovascular effects. Strict laboratory safety practices are required.
| Hazard Classification (GHS) | Symbol | Precautionary Measures |
|---|---|---|
| Acute toxicity | ⚠️ | Avoid ingestion or inhalation; use PPE |
| CNS active compound | ⚠️ | Handle in ventilated fume hoods |
| Eye/Skin irritation | ⚠️ | Use gloves, goggles, lab coat |
| Environmental hazard | ☣️ | Dispose via licensed chemical waste channels |
Best Practices:
- Use fume hoods or ventilated enclosures
- Store in airtight, light-protected containers at 2–8 °C
- Maintain proper documentation, labeling, and regulatory compliance
Transactional: Regulatory Status
4F-MDMB-BINACA is classified as a controlled synthetic cannabinoid in most countries.
| Region / Country | Legal Classification | Regulatory Reference |
|---|---|---|
| United States | Schedule I analogue / NPS | DEA Controlled Substances Act |
| European Union | Controlled NPS | EMCDDA early warning system |
| United Kingdom | Class B (Psychoactive Substances Act) | Home Office, 2016 |
| Canada | Schedule II analogue | Health Canada Controlled Drugs and Substances Act |
| Australia | Schedule 9 (Poison) | Therapeutic Goods Administration |
✅ Only licensed laboratories may legally acquire 4F-MDMB-BINACA powder for research, analytical, or educational purposes.
Comparative Table: 4F-MDMB-BINACA vs Other Synthetic Cannabinoids
| Compound | Chemical Class | Potency | Research Use | Legal Status |
|---|---|---|---|---|
| 4F-MDMB-BINACA | Indazole-based cannabinoid | Extremely High | Analytical & metabolic research | Controlled |
| 5F-MDMB-2201 | Indazole-based cannabinoid | Very High | Pharmacology & toxicology | Controlled |
| AB-FUBINACA | Indazole-based cannabinoid | Extremely High | Forensic & analytical | Controlled |
| CUMYL-PEGACLONE | Gamma-carboline cannabinoid | High | Analytical & receptor studies | Controlled |
This table assists researchers and forensic analysts in understanding structural, potency, and regulatory differences.
Research and Forensic Significance
4F-MDMB-BINACA is critical for:
- NPS monitoring and forensic toxicology
- Developing LC-MS/MS and GC-MS analytical methods
- Studying synthetic cannabinoid metabolism and toxicity
- Training forensic and laboratory professionals
Although recreational use is illegal, its research applications support public health, forensic science, and regulatory compliance.
Conclusion
4F-MDMB-BINACA powder is a potent synthetic cannabinoid for research, analytical, and forensic purposes. Proper handling requires licensed, compliant laboratories, safety measures, and strict adherence to legal regulations.
For analytical chemists, forensic scientists, and pharmacologists, 4F-MDMB-BINACA provides a valuable tool for understanding synthetic cannabinoid pharmacology, metabolism, and detection methods.
Keywords
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