3-MPHP Powder: Forensic Research, Properties, and Regulatory Overview
Introduction
3-MPHP (3′-Methyl-α-pyrrolidinohexiophenone) is a synthetic cathinone derivative belonging to the pyrrolidinophenone class of compounds. Originally synthesized for forensic and toxicological research, 3-MPHP has gained attention due to its structural similarity to compounds like α-PVP and MDPV, which are well-studied stimulants in the field of psychoactive substance analysis.
In modern laboratories, 3-MPHP serves as a reference material, analytical standard, and casework comparison compound in forensic toxicology and substance identification. This article provides a detailed overview of 3-MPHP’s chemical characteristics, laboratory relevance, safety guidelines, and regulatory considerations, ensuring compliance with legal frameworks worldwide.
Informational: Chemical Identity and Characteristics
3-MPHP is a substituted cathinone, structurally related to α-PHP (α-pyrrolidinohexanophenone). It contains a methyl group on the phenyl ring and a pyrrolidine ring attached to the alpha carbon. These structural features influence its chemical stability, volatility, and chromatographic behavior — all critical factors for analytical laboratories.
Chemical Properties Table
| Property | Details |
|---|---|
| Chemical Name | 3′-Methyl-α-pyrrolidinohexiophenone |
| Abbreviation | 3-MPHP |
| CAS Number | 1354631-26-3 (reference for research use only) |
| Molecular Formula | C17H25NO |
| Molecular Weight | 259.39 g/mol |
| IUPAC Name | 1-(3-methylphenyl)-2-(pyrrolidin-1-yl)hexan-1-one |
| Appearance | Off-white to light beige crystalline powder |
| Solubility | Soluble in ethanol, methanol, and organic solvents |
| Storage Conditions | Store in cool, dry, and dark conditions; avoid moisture |
| Purity (for reference standards) | ≥98% (HPLC verified) |
| Research Use | Forensic toxicology, reference testing, GC-MS/LC-MS method development |
These chemical identifiers and purity levels help ensure traceability and reproducibility during forensic and toxicological testing.
Navigational: Forensic and Analytical Applications
Forensic laboratories and toxicologists use 3-MPHP primarily for analytical method validation and casework confirmation. Since it can appear as a new psychoactive substance (NPS) in seized material, validated reference data is crucial for accurate identification.
Analytical Detection Methods
- Gas Chromatography–Mass Spectrometry (GC-MS): Standard approach for substance identification using retention times and fragmentation patterns.
- Liquid Chromatography–Mass Spectrometry (LC-MS/MS): Provides sensitivity and specificity for detecting trace levels in biological matrices.
- Infrared (IR) Spectroscopy: Used to confirm characteristic functional group peaks (carbonyl, aromatic, pyrrolidine).
- Nuclear Magnetic Resonance (NMR): Confirms structural integrity for research-grade samples.
Sample Handling & Preparation
3-MPHP is typically handled in trace quantities in controlled laboratory environments. Laboratory technicians must wear personal protective equipment (PPE) and follow chemical hygiene standards to prevent exposure and contamination.
Commercial: Sourcing Reference Standards and Research Supplies
Because 3-MPHP is controlled or restricted in many regions, it is not commercially distributed for human or recreational use. However, certified analytical reference suppliers and accredited chemical companies may offer 3-MPHP reference solutions or analytical-grade powders under strict compliance protocols.
Legitimate Use Cases Include:
- Forensic science research for toxicological profiling.
- Law enforcement training on synthetic cathinone identification.
- Pharmaceutical impurity reference comparisons in drug development.
- Academic studies on structure-activity relationships (SAR).
Reputable suppliers comply with ISO/IEC 17025 or ISO 9001 standards for analytical quality assurance. Each batch is accompanied by a Certificate of Analysis (CoA) and Safety Data Sheet (SDS) for regulatory documentation.
Transactional: Legal and Regulatory Framework
Due to its similarity to other psychoactive stimulants, 3-MPHP is scheduled or controlled in several jurisdictions under analog acts or new psychoactive substance regulations. The degree of control varies by country:
| Region | Legal Status | Regulatory Reference |
|---|---|---|
| United States | Controlled under Federal Analogue Act | DEA Schedule I equivalent |
| European Union | Controlled as a cathinone derivative | EMCDDA reporting framework |
| United Kingdom | Classified under the Psychoactive Substances Act 2016 | Prohibited for non-research use |
| Canada | Schedule I under CDSA | Permitted for licensed research only |
| Australia | Controlled Substance (Schedule 9) | Restricted to approved laboratories |
To remain compliant, institutions must:
- Hold a research or analytical license if required by national law.
- Maintain inventory control and record all handling of 3-MPHP reference materials.
- Dispose of unused material following hazardous waste protocols.
Health, Safety, and Environmental Considerations
3-MPHP may pose toxicological risks if mishandled. While data is limited, its structural similarity to stimulants suggests potential neurochemical activity and acute toxicity. For laboratory personnel, it’s vital to observe the following:
- Use in fume hoods or ventilated enclosures.
- Avoid skin contact or inhalation.
- Dispose of contaminated materials in accordance with EPA and local chemical disposal regulations.
Environmental release must be prevented, as synthetic cathinones can impact wastewater toxicity and aquatic systems.
Conclusion: Responsible Research and Compliance 3-MPHP powder near
3-MPHP powder remains a valuable tool for forensic laboratories, analytical chemists, and regulatory agencies focused on NPS monitoring and toxicological analysis. When sourced legally from certified reference suppliers, it aids in the accurate identification, profiling, and classification of psychoactive substances — contributing to public health and safety.
Institutions engaging with this compound should ensure regulatory compliance, ethical research standards, and transparent documentation of all analytical work.
3-MPHP powder online Key Takeaways
- 3-MPHP is a forensic reference compound, not for human use.
- Essential for toxicology research, law enforcement, and analytical validation.
- Legally restricted — must be handled under licensed laboratory conditions.
- Purchase only from certified suppliers with complete documentation (CoA, SDS).
- Supports global efforts to monitor and regulate emerging psychoactive substances.
Properties:
- Class: Stimulant, related to the pyrrolidinophenone class
- Effects: 3-MPHP is known for its stimulant properties, similar to other compounds in the pyrrolidinophenone class, such as α-PVP. The effects include increased energy, alertness, and euphoria.
Uses:
- Research: Used in scientific studies to explore stimulant effects. It’s valuable in pharmaceutical research due to its stimulant properties.
Purchasing Information:
- Quality: Ensure the supplier provides high-purity MPHP, ideally above 99%. Quality assurance is critical due to the sensitive nature of this compound.
- Suppliers: Look for reputable chemical supply companies or manufacturers. Companies like Global Chemical Online are known for high-quality production and adherence to manufacturing standards.
Considerations for Buying:
- Legality: Verify the legal status of MPHP in your region. While it may be legal in some places, always ensure compliance with local regulations.
- Privacy: When purchasing online, choose suppliers that offer discreet packaging and secure transactions.
- Handling and Storage: Store in a cool, dry place away from sunlight. Handle with appropriate safety gear and ensure good ventilation.
Where to Buy:
- Online Suppliers: Reputable chemical supply companies often list 3-MPHP. Look for those that offer detailed product specifications and have a track record of reliability.
- Wholesale: Many suppliers offer bulk purchasing options. Ensure they provide certifications and adhere to safety and quality standards.
Example Suppliers:
- Global Chemical Online: Known for high-quality products and reliable service. They offer various options for purchasing MPHP, including wholesale.
Important Notes:
- Research Only: 3-MPHP is intended for research purposes only and is not for human consumption.
- Confidentiality: Some suppliers offer personal accounts for ordering, ensuring privacy and confidentiality.
If you need further assistance with purchasing or have specific requirements, feel free to ask!









