Buy CUMYL-PEGACLONE/ Synthetic cannabinoids/ sgt151 /CAS NO. 8378-23-2

CUMYL-PEGACLONE: Synthetic Cannabinoid Overview, Properties, and Research Applications

Introduction

                          CUMYL-PEGACLONE is a synthetic cannabinoid belonging to the gamma-carboline family, often studied as a research chemical for its interactions with CB? and CB? receptors. While it has been identified in “designer cannabis” products in the past, it is now primarily of interest in forensic toxicology, pharmacological research, and regulatory monitoring.

The compound is fully controlled in many jurisdictions, but legal access is available for licensed laboratories, academic studies, and analytical reference purposes. Understanding CUMYL-PEGACLONE is critical for researchers, regulatory agencies, and forensic scientists.

Informational: Chemical Identity and Properties

Mechanism of Action

CUMYL-PEGACLONE acts as a potent agonist of cannabinoid receptors (CB? and CB?), mimicking the effects of naturally occurring cannabinoids like THC, but with higher receptor binding affinity. In research settings, it is used to study:

• Receptor-ligand interactions
• Synthetic cannabinoid pharmacology
• Metabolic and toxicological profiles

Navigational: Forensic and Analytical Applications

Synthetic cannabinoids such as CUMYL-PEGACLONE pose challenges in forensic toxicology because of their rapid structural evolution and high potency.

Key Applications in Research

1. Reference Standards – Used in labs to validate detection and quantification methods for new psychoactive substances (NPS).
2. Metabolic Studies – Helps determine metabolites in blood, urine, or tissue samples.
3. Analytical Method Development – Improves detection accuracy via LC-MS/MS, GC-MS, and NMR.
4. Forensic Education – Serves as a case study for legal and regulatory compliance.

Analytical Techniques

These methods allow labs to differentiate CUMYL-PEGACLONE from other synthetic cannabinoids, ensuring accurate forensic reporting.

Commercial: Legal and Licensed Supply

CUMYL-PEGACLONE is strictly controlled in most countries, but legal research access is available under license.

Note: Purchase and handling of CUMYL-PEGACLONE must comply with all local, national, and international laws, including documentation and chain-of-custody requirements.

Health, Safety, and Handling

CUMYL-PEGACLONE is highly potent, and accidental exposure can cause severe neurological or cardiovascular effects. Safe laboratory practices are essential.

Laboratory Best Practices:

• Work in ventilated enclosures or fume hoods.
• Store in light-protected, dry containers at low temperatures.
• Maintain accurate documentation and chain-of-custody records.

Transactional: Regulatory Status

CUMYL-PEGACLONE is regulated under various national laws due to its psychoactive properties.

? Only licensed research labs and forensic institutions may legally handle CUMYL-PEGACLONE.

Comparative Table: CUMYL-PEGACLONE vs Other Synthetic Cannabinoids

This table is helpful for researchers comparing structural and pharmacological differences among synthetic cannabinoids.

Scientific and Regulatory Significance

Studying CUMYL-PEGACLONE helps laboratories:

• Update forensic and toxicology databases for law enforcement.
• Identify new psychoactive substances in seized products.
• Support regulatory compliance and early-warning systems for public health.

Despite its restricted legal status, CUMYL-PEGACLONE remains a critical research tool for understanding synthetic cannabinoid pharmacology and metabolism.

Conclusion

CUMYL-PEGACLONE is a synthetic cannabinoid of high forensic and research importance. While strictly controlled, it is legally accessible to licensed laboratories for analytical, pharmacological, and toxicological studies.

Researchers, forensic analysts, and regulatory professionals benefit from understanding its chemical properties, receptor activity, analytical detection methods, and legal compliance requirements. Adhering to safety, storage, and documentation protocols ensures responsible handling of this potent compound.

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Buy CUMYL-PEGACLONE/ Synthetic cannabinoids/ sgt151 /CAS NO. 8378-23-2

Purchase (SGT-151) CUMYL-PEGACLONE Online

Buy CUMYL-PEGACLONE/ Synthetic cannabinoids/ sgt151 /CAS NO. 8378-23-2We offer high-quality SGT-151 for sale, which is also known by the name CUMYL-PEGACLONE. SGT-151, or CUMYL-PEGACLONE, is a synthetic cannabinoid classified under the indazole-3-carboxamide category. It shares structural similarities with cumyl-PICA. This compound acts as a potent agonist for both CB1 and CB2 receptors, with a significantly higher binding affinity for the CB1 receptor.

Suppliers of SGT-151 CUMYL-PEGACLONE

Various cannabinoids can be transformed into non-cannabinoid substances. However, SGT-151 is notably resistant to such transformations, maintaining its cannabinoid core. It is relatively easier to convert SGT-151 into other cannabinoid substances.

Being a recent addition to the market, the toxicity and other characteristics of this substance are still being investigated. It is crucial to avoid using it for recreational purposes. Researchers and chemists can purchase SGT-151 as a research chemical for experimental purposes. Proper laboratory equipment should be used when handling this compound, as it can produce significant effects on the human body.

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CUMYL-PEGACLONE (SGT-151) is a synthetic cannabinoid based on a gamma-carboline framework, marketed as a designer drug. The gamma-carboline core structure found in CUMYL-PEGACLONE was unprecedented in designer cannabinoids before its discovery, although it bears structural resemblances to other gamma-carboline cannabinoids described by Bristol-Myers Squibb in 2001.

5F-SGT-151 (5F-CUMYL-PEGACLONE) is a synthetic cannabinoid that has gained popularity among researchers across Europe and the USA. It shares several characteristics with 5F-ADB but exhibits a much greater affinity for the CB1 receptor.

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CUMYL-PEGACLONE is the shortened name for 5-pentyl-2-(1-methyl-1-phenyl-ethyl)-2,5-dihydro-pyrido[4,3-b]indol-1-one, representing a new generation of novel synthetic cannabinoids. It is currently not controlled in most EU countries for laboratory research purposes.

Important Notice: This compound has an exceptionally high in-vitro affinity for the CB1 receptor, surpassing even that of 5F-ADB. Adhere to laboratory safety protocols, including the use of respirator masks and gloves when handling this substance.

From a regulatory standpoint, the significant feature of the SGT-151 molecule is that the ring and bridge are part of the same substructure. This characteristic helps it avoid generic controls used by some EU nations like Germany, where controls are based on the JWH-018 “4 substructure” template.

Given the limited knowledge about its chemical properties, SGT-151 offers an exciting opportunity for researchers and chemistry enthusiasts to conduct pioneering experiments. This includes exploring fundamental chemical and physical properties such as melting points and solubilities.

Buy CHM-SGT-151 CUMYL-PEGACLONE (SGT-151)

Acquire CHM-SGT-151 CUMYL-PEGACLONE (SGT-151) from our online research chemical store. CHM-SGT-151 is a gamma-carboline-based synthetic cannabinoid, marketed as a designer drug. The gamma-carboline core structure in CUMYL-PEGACLONE had not been previously identified in designer cannabinoids, though it shares structural similarities with gamma-carboline cannabinoids disclosed by Bristol-Myers Squibb in 2001.

Order CHM-SGT-151 online from our virtual research chemical shop for convenient doorstep delivery. CHM-SGT-151 is widely used in laboratory research across Europe and the USA and is known as CUMYL-PeGaCLONE. The formal designation for CHM-SGT-151 is 2,5-dihydro-2-(1-methyl-1-phenylethyl)-5-pentyl-1H-pyrido[4,3-b]indol-1-one, with a molecular formula of C25H28N2O and a formula weight of 372.5. This potent agonist strongly binds to CB1 cannabinoid receptors.

Please Note: While the toxicological and physiological properties of CHM-SGT-151 have not been extensively studied, our high-quality packaging ensures the integrity of your order. You can also review customer feedback and product descriptions to gauge the quality of our offerings. We are committed to providing reliable and affordable products and are equipped to handle both small and large orders.

Synonyms:

• SGT-151

Technical Information:

• Formal Name: 2,5-dihydro-2-(1-methyl-1-phenylmethyl)-5-pentyl-1H-pyrido[4,3-b]indol-1-one
• CAS Number: 2160555-55-3
• Molecular Formula: C25H28N2O
• Formula Weight: 372.5
• Purity: ?98%
• Formulation: Crystalline solid
• Solubility:
  • DMF: 30 mg/ml
  • DMF

    (pH7.2) (1:2): 0.25 mg/ml

  • DMSO: 15 mg/ml
  • Ethanol: 1 mg/ml
  • Methanol: 1 mg/ml
• ?max: 252 nm

SMILES: CC(C1=CC=CC=C1)(C)N2C=CC(N(C)C3=C4C=CC=C3)=C4C2=O InChi Code: InChI=1S/C25H28N2O/c1-4-5-11-17-26-21-15-10-9-14-20(21)23-22(26)16-18-27(24(23)28)25(2,3)19-12-7-6-8-13-19/h6-10,12-16,18H,4-5,11,17H2,1-3H3 InChi Key: AWHWTKXMUJLSRM-UHFFFAOYSA-N

Shipping & Storage Information:

• Storage: -20°C
• Shipping: Room temperature in the continental US; may vary elsewhere
• Stability: ?2 years

CUMYL-PEGACLONE initially appeared on the market in herbal blends and e-liquids before becoming available as a pure research chemical in July 2017. Research groups have since characterized this compound, including its metabolism and cannabinoid activity. The psychoactive effects, largely attributed to CB1 receptor activation, are accompanied by various adverse effects.

Note: Although initial assessments suggested ?-carbolinone-based SCRAs might be relatively safe, several fatalities have been reported, raising concerns about the relative safety of ?-carbolinones. Fluorination could potentially increase potency and toxicity, but data to confirm this are lacking.

The compound 5-pentyl-2-(2-phenylpropan-2-yl)-2,5-dihydro-1H-pyrido [4,3-b]indol-1-one (known as CUMYL-PEGACLONE or SGT-151) was the first SC with a ?-caroline core detected in forensic casework, and it has since been prevalent in the German SC market. It was found in approximately 25% of herbal blends purchased in Germany and has shown high prevalence in biological samples.

High NPS has contributed to toxicity and fatalities, although no cases have conclusively linked CUMYL-PEGACLONE as a causative factor. Its relatively low incidence of severe intoxications and deaths has led to its classification as a “comparatively safe drug,” though its overall toxicity remains under review. The metabolic processes of 5F-Cumyl-PEGACLONE favor the 5-fluorophenyl side chain and ?-caroline core structure, contrasting with other analogs like 5F-Cumyl-PICA and 5F-Cumyl-PINACA.