Purchase Levamisole Powder Online
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Levamisole Hydrochloride Powder /CAS 16595-80-5. Procure Levamisole Powder via online platforms. Levamisole Hydrochloride (CAS Number 16595-80-5) is a nicotinic receptor agonist utilized primarily to treat helminthic infections and certain dermatological conditions. Buy Levamisole (CAS Number 16595-80-5), a synthetic derivative of imidazothiazole, is extensively employed in treating worm infestations affecting both humans and animals. As an anthelmintic, its mechanism likely involves targeting the nematode nicotinic acetylcholine receptor. Additionally, as an immunomodulator, Levamisole has demonstrated effectiveness in enhancing immune response, particularly in conjunction with 5-Fluorouracil (5FU) for patients with Stage III colon cancer.
Levamisole Overview
Levamisole, marketed under the brand name Ergamisol among others, is a medication used to address parasitic worm infections, notably ascariasis and hookworm infestations. It is administered orally. Levamisole has been associated with several side effects, including abdominal discomfort, vomiting, headaches, and dizziness. It is advised against use during breastfeeding or the third trimester of pregnancy due to potential risks. Serious adverse effects may include an increased susceptibility to infections. Levamisole is classified as an anthelmintic medication.
Historical Context and Usage
Discovered in 1966, Levamisole is listed on the World Health Organization’s List of Essential Medicines. It is not commercially available in the United States but is also utilized as a dewormer for livestock. Initially manufactured by Janssen, Levamisole was introduced in 1969 for treating worm infestations and received FDA approval in 1990 as an adjuvant therapy for colon cancer. In the 1970s and 1980s, it was also used as an antirheumatic therapy for patients with rheumatoid arthritis. Levamisole was withdrawn from the American market in 2000 due to severe adverse effects, including agranulocytosis. Interestingly, it has been detected as an adulterant in cocaine, leading to various health complications.
Levamisole Hydrochloride Powder Details
- Classification: Antiparasitic Agents
- CAS Number: 16595-80-5
- Chemical Name: Levamisole Hydrochloride
- Molecular Formula: C11H13ClN2S
- Appearance: White or almost white crystalline powder
- Purity: 98.5% – 101.0%
- Storage: Store at temperatures between 0°C and 6°C
- Packaging: 25 kg per drum
- Delivery: Available by courier, air, or sea
- Production Capacity: 75 Metric Tons per year
- Limit Number: 25 kilograms
- Related Substances: Complies
- Residue on Ignition: ≤0.1%
- Heavy Metals: ≤20 ppm
- Validity: 4 years
- pH: 3.0 – 4.5
- Color: White
Pharmacological Action
Levamisole hydrochloride, a left-turning isomer, is a biologically active derivative of tetramisole, belonging to the imidazole group. It inhibits acetylcholinesterase enzyme activity, blocking ATP formation, and affecting the neuromuscular system of parasites. This inhibition causes muscle contraction and paralysis in parasites, leading to their death within 12 to 24 hours of administration. In animals, Levamisole is metabolized to oxy-mercapto imidazolidine, which positively influences the immune system of mammals and birds.
Applications and Dosage
Levamisole is used for deworming cattle, sheep, pigs, dogs, and birds (including chickens, geese, turkeys, and pigeons) against gastrointestinal and pulmonary nematode infestations. Specific dosage recommendations include:
- Cattle, Sheep, Pigs, Dogs: 1 gram per 10 kilograms of body weight, administered orally with water or feed.
- Birds: 3-4 grams per 10 kilograms of body weight, administered orally with water in a single dose or divided over 3-4 days.
- Pigeons: 1 gram per glass of water, replacing all drinking water for 3-5 days.
Contraindications and Warnings
Levamisole should not be used in the final third of pregnancy, during the breeding season, or in laying hens and weakened animals. It should also not be used in conjunction with pyrantel, morantel, organophosphates, or neostigmine. Post-treatment, animals can be slaughtered after 7 days, and milk and eggs can be consumed after 3 days. If slaughtered before this period, meat should be used for feeding carnivorous animals or for meat and bone meal production, and milk should be fed to non-productive animals.
Storage Instructions
Store Levamisole in a dry, dark place at temperatures ranging from +1°C to +25°C.
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For purchasing Levamisole Powder online, ensure you obtain high-quality product specifications and adhere to all safety guidelines.
