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Ketamine Crystal appears as a white, crystalline powder or a clear liquid. You can purchase Ketamine Crystal Powder online without requiring a prescription.
Alternative Names for Ketamine Crystal Powder
Ketamine is also known by various names including (+/-)-2-(2-chlorophenyl)-2-(methylamino)-cyclohexanone; commercially available as Ketalar®, Ketaject®, Ketaset®, and Vetalar®; colloquially referred to as K, Special K, Vitamin K, Lady K, Jet, Super Acid, Bump, Special LA Coke, KitKat, and Cat Valium. Buy Ketamine Crystal Powder Online Without a Prescription.
Drug Classification
Ketamine falls under several categories: it is classified as a dissociative anesthetic, hallucinogen, and psychotomimetic substance.
Medical and Recreational Uses of Ketamine Crystal Powder
Primarily, ketamine is utilized in veterinary medicine as a tranquilizer. In human medicine, it serves as an anesthetic induction agent used before the administration of general anesthetics for diagnostic and surgical procedures. Occasionally, it is employed as a short-acting general anesthetic for pediatric and elderly patients. Recreationally, ketamine is used for its psychedelic properties and dissociative effects. Buy Ketamine Crystal Powder Online Without a Prescription.
Potency, Purity, and Dosage
Ketamine is available in a racemic mixture form, with the S-(+)-isomer exhibiting greater potency than the R-(-)-isomer. It is commercially supplied as the hydrochloride salt, typically in concentrations of 0.5 mg/mL and 5 mg/mL ketamine base equivalents. For inducing 5-10 minutes of surgical anesthesia, the recommended intravenous dose is between 1.0 and 4.5 mg/kg; for intramuscular administration, the dose is 6.5 to 13 mg/kg, providing 12-25 minutes of surgical anesthesia. The injectable solution can be gently heated to evaporate water, leaving a white powder (ketamine hydrochloride) which can be snorted or ingested orally. Recreational dosages vary widely, with common doses being 25-50 mg intramuscularly, 30-75 mg by snorting, and 75-300 mg orally. Snorting a small amount (“bump,” 30-50 mg) typically results in a dreamy effect. A “K-hole,” characterized by profound dissociation, can be achieved with a dose of 60-125 mg intramuscularly, or 100-250 mg by snorting. Impurities are rarely observed, though ketamine hydrochloride may occasionally be used as an adulterant in heroin. Buy Ketamine Crystal Powder Online Without a Prescription.
Routes of Administration
Ketamine can be administered through various routes: injection, snorting, oral ingestion, and rectal administration. It can also be added to tobacco or marijuana cigarettes and smoked, similar to phencyclidine (PCP).
Pharmacodynamics
Ketamine’s effects involve analgesia, anesthesia, and sympathomimetic actions mediated through distinct mechanisms. The analgesic effects are primarily due to non-competitive antagonism of NMDA receptors. Opiate receptors might contribute to analgesia and dysphoric reactions, while sympathomimetic effects could result from enhanced central and peripheral monoaminergic transmission. Ketamine blocks dopamine uptake, thereby increasing synaptic dopamine levels. Additionally, inhibition of cholinergic transmission might contribute to its anesthetic and hallucinogenic effects. Structurally, ketamine is similar to PCP but is 10-50 times less potent in blocking NMDA receptor effects.
Pharmacokinetics
Following intramuscular administration, ketamine’s bioavailability is 93%, while intranasal administration yields 25-50%, and oral administration results in 20±7%. Ketamine rapidly distributes into the brain and other highly perfused tissues, with 12% plasma protein binding. The plasma half-life is approximately 2.3 ± 0.5 hours. Oral administration results in lower peak ketamine concentrations but higher levels of metabolites like norketamine and dehydronorketamine. Ketamine and its metabolites undergo hydroxylation and conjugation, with ketamine producing effects similar to ketamine. The pharmacokinetic properties of the S-(+) and R-(-) isomers are not significantly different.
Molecular Interactions / Receptor Chemistry
Ketamine’s N-demethylation to norketamine is primarily catalyzed by the enzyme cytochrome P450 3A4, with minor contributions from CYP2B6 and CYP2C9 isoforms. Potential inhibitors of these isoenzymes may reduce the rate of ketamine elimination if used concurrently, while inducers could accelerate its elimination.
Interpreting Blood Concentrations
Ketamine concentrations do not directly correlate with behavioral effects. Drowsiness, perceptual distortions, and intoxication may be dose-dependent within a range of 50 to 200 ng/mL, with analgesia beginning at around 100 ng/mL. During anesthesia, blood ketamine concentrations typically range from 2000-3000 ng/mL, with patients starting to awaken when levels decrease to 500-1000 ng/mL.
Interpreting Urine Test Results
Unchanged ketamine is excreted in urine at about 4±3%, and ketamine use can be detected in urine for approximately 3 days. Urinary concentrations of ketamine can vary from as low as 10 ng/mL to as high as 25,000 ng/mL.
Effects of Ketamine Crystal Powder
Physically, ketamine’s effects are likened to those of PCP, with visual effects compared to LSD.
Psychological Effects
Users may experience decreased awareness of their surroundings, sedation, a dream-like state, vivid dreams, feelings of invulnerability, increased distractibility, disorientation, and limited communication. Hallucinations, impaired thought processes, out-of-body experiences, and altered perceptions of body, environment, time, and sound may occur. Delirium and hallucinations can persist after waking from anesthesia.
Physiological Effects
Effects include anesthesia, cataplexy, immobility, tachycardia, elevated blood pressure, nystagmus, increased salivation, elevated urinary output, profound insensitivity to pain, amnesia, slurred speech, and impaired coordination.
Side Effect Profile
Common adverse effects include anxiety, chest pain, palpitations, agitation, rhabdomyolysis, flashbacks, delirium, dystonia, psychosis, schizophrenic-like symptoms, dizziness, vomiting, seizures, and paranoia.
Duration of Effects
Onset is rapid if smoked (seconds), 1-5 minutes if injected, 5-10 minutes if snorted, and 15-20 minutes if ingested orally. Effects generally last 30-45 minutes after injection, 45-60 minutes after snorting, and 1-2 hours following oral ingestion. Due to its short duration, ketamine is often readministered. Some users may continue to experience dreams 24 hours later. Marked dissociative effects, schizotypal symptoms, and impaired memory may persist for days after use.
Tolerance, Dependence, and Withdrawal
Long-term use can lead to high tolerance, drug cravings, and flashbacks. There is minimal evidence of a physiological withdrawal syndrome, except in cases of abrupt discontinuation in chronic users.
Drug Interactions
Midazolam can reduce altered perception and thought processes caused by ketamine. Lorazepam may mitigate emotional distress but does not affect cognitive or behavioral impacts. Diazepam increases ketamine’s half-life. Lamotrigine decreases perceptual abnormalities but enhances mood elevation. Haloperidol might reduce impairment in executive functions but does not affect psychosis or other symptoms. Alfentanil’s effects are additive to ketamine, while physostigmine and 4-aminopyridine can counteract some pharmacodynamic effects.
Performance Effects
Ketamine induces a broad spectrum of cognitive impairments and pronounced dissociative effects. These include increased distractibility, intense visual or multisensory hallucinations, impaired immediate and delayed recall, and decreased language function. The S-(+) isomer impairs psychomotor function 3-5 times more than the R-(-) isomer.
DEC Profile
Indicators include horizontal and vertical gaze nystagmus, lack of convergence, normal pupil size and light reaction, elevated pulse rate, blood pressure, and body temperature. Other potential signs are muscle rigidity, cyclical behavior, and unresponsiveness to painful stimuli.
Driving Risks
The use of ketamine significantly impairs the skills necessary for safe driving due to its moderate to severe psychomotor, cognitive, and residual effects. Buy Ketamine Crystal Powder Online Without a Prescription.
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