Purchase bulk Thyrotropin TRH (Thyrotropin-Releasing Hormone), CAS No. 9002-71-5, at factory prices.
Buy wholesale Thyrotropin TRH CAS NO. 9002-71-5 factory price: Thyrotropin-releasing hormone (TRH) is a hypophysiotropic hormone produced by neurons in the hypothalamus that stimulates the release of thyroid-stimulating
Product Overview
- Product Name: Thyrotropin TRH
- CAS Number: 9002-71-5
- Synonyms: Protirelin, Thyrotropin Releasing Hormone
- Chemical Formula: C18H26N6O6
- Molecular Weight: 422.44 g/mol
- Appearance: Lyophilized powder
- Purity: 99%
- Grade: Pharmaceutical/Research Grade
- Storage Conditions: 2-8°C
Applications of TRH in Research
- Depression and Suicidal Ideation:
- TRH has long been explored for its potential antidepressant effects.
- The U.S. Army-funded research into a TRH-based nasal spray in 2012 aimed at reducing suicide rates among soldiers.
- Studies dating back to the 1970s demonstrated that TRH reduced suicidal thoughts in severely depressed patients. Though spinal administration of TRH showed efficacy, research has shifted towards more practical delivery methods such as IV and intranasal administration.
- TRH administered at night demonstrated extended antidepressant effects lasting up to 48 hours, suggesting its potential for long-term depression management.
- Motor Memory and Cerebellar Function:
- Motor memory (muscle memory) is crucial for tasks like typing and playing instruments, and TRH plays a role in its development.
- Research in mice lacking the gene for TRH showed slower learning in motor tasks, but speed improved with TRH administration.
- TRH has also been shown to help reduce symptoms of cerebellar degenerative diseases, improving motor coordination and reducing ataxia.
- Opioid Overdose Treatment:
- TRH has shown promise in reducing respiratory depression caused by opioid overdoses, a condition that naloxone (Narcan) currently treats.
- Unlike naloxone, TRH increases breathing rates without reducing pain control, making it a promising alternative for opioid overdose intervention.
- Trauma and Shock Research:
- Taltirelin, a more stable analogue of TRH, has been tested in trauma settings like hemorrhagic shock, demonstrating its ability to improve blood pressure, oxygen levels, and blood pH.
- TRH could become a key treatment in managing acute blood loss during emergencies.
- Aging and Neuroprotection:
- TRH has been shown to reduce amyloid plaque buildup in organs like the kidneys, helping preserve organ function with age.
- Although its impact on Alzheimer’s disease (AD) is still being explored, TRH levels are known to drop in patients with AD, and supplementation might be beneficial.
Safety and Handling Information
- Hazard Code: B
- Transport Information: RIDADR NONH (non-hazardous for all transport modes)
- WGK Germany Classification: 3
- RTECS: XP3581600
Packaging and Supply
- Available in 20 mg and 50 mg vials with 99% purity.
- Storage: 2-8°C for optimal stability.
- TRH is for research and educational purposes only. It is not intended for human consumption without proper authorization.
Order Details
- MOQ: 1 gram
- Supply Capacity: Available every month from a reputable factory source in China.
- Lead Time: Based on order size and region.
Researchers interested in TRH for various experimental applications can benefit from its wide range of potential therapeutic uses, including depression, motor memory, overdose prevention, and trauma recovery.
