Buy EAM-2201 powder / CAS 1364933-60-7 / online
Introduction
EAM-2201 (chemical name: 1-(5-fluoropentyl)-1H-indol-3-yl-methanone) is a synthetic cannabinoid belonging to the naphthoylindole family. It was first synthesized in the early 2010s as part of legitimate pharmacological research into cannabinoid receptor activity. However, due to its structural similarity to JWH-210 and AM-2201, EAM-2201 soon appeared in unregulated “herbal incense” and “legal high” products — leading to widespread forensic attention and legal control.
Today, EAM-2201 powder is classified as a controlled substance in most jurisdictions. It is legally handled only by licensed laboratories for purposes such as analytical method validation, toxicological research, and forensic reference calibration.
EAM-2201 Powder: Chemical Profile, Forensic Applications, and Legal Regulation
Informational: Chemical Identity and Properties
| Property | Details |
|---|---|
| Chemical Name | 1-(5-Fluoropentyl)-1H-indol-3-yl-methanone |
| Common Names | EAM-2201, F-EAM-2201, synthetic cannabinoid reference standard |
| Chemical Formula | C₂₆H₂₆FNO |
| Molecular Weight | 387.48 g/mol |
| CAS Number | 1354631-23-5 |
| Chemical Class | Indole-based naphthoyl compound (synthetic cannabinoid) |
| Appearance | White to light beige crystalline powder |
| Solubility | Soluble in ethanol, methanol, and DMSO; insoluble in water |
| Boiling Point | ~470 °C (decomposes) |
| Storage Conditions | Keep sealed, dry, and protected from light (2–8 °C) |
Structural Overview
EAM-2201 consists of an indole core linked to a naphthoyl group and a fluorinated pentyl side chain. This structure enables high affinity for CB₁ and CB₂ receptors, mimicking the effects of Δ⁹-THC but with greater potency.
The compound is typically synthesized in small quantities for controlled laboratory use, not for consumer or pharmaceutical markets.
Navigational: Forensic and Analytical Applications
EAM-2201 is primarily studied in forensic toxicology and analytical chemistry contexts to aid in the identification of synthetic cannabinoids in biological and environmental samples.
Key Forensic Applications
- Reference Standards – Used by accredited labs to validate cannabinoid detection methods.
- Toxicological Research – Helps determine metabolic pathways and metabolites in biological samples.
- Method Development – Used to improve LC-MS/MS, GC-MS, and FT-IR detection protocols.
- Educational Use – Provides a benchmark for chemistry programs studying receptor binding or molecular modeling.
Common Analytical Methods
| Technique | Purpose | Notable Features |
|---|---|---|
| GC-MS (Gas Chromatography–Mass Spectrometry) | Identify molecular fragments | Fragments at m/z 144, 214 characteristic of fluoropentyl chain |
| LC-MS/MS (Liquid Chromatography–Tandem MS) | Quantify trace levels in blood or urine | Parent ion at m/z 386, strong signal at 214 |
| FT-IR (Fourier Transform Infrared) | Confirm presence of indole and carbonyl groups | Strong C=O stretch at 1685 cm⁻¹ |
| ¹H/¹³C NMR | Structure elucidation | Diagnostic aromatic signals at 7–8 ppm |
These analytical techniques are vital for maintaining up-to-date forensic databases used by agencies such as the DEA, EMCDDA, and UNODC.
Commercial: Legal and Licensed Supply Channels
Due to its classification, EAM-2201 powder can only be distributed through authorized reference material suppliers or research institutions holding valid licenses for controlled substances.
| Supplier Category | License Requirement | Intended Use |
|---|---|---|
| ISO 17034-accredited reference material producers | DEA / EMCDDA / national chemical license | Analytical calibration and quality control |
| Academic research labs | Institutional ethics approval | Receptor binding and metabolism studies |
| Forensic laboratories | Controlled substance permit | Confirmatory testing and proficiency evaluation |
All legal transactions require:
- Verified institutional affiliation
- Import/export control permits
- Certificate of Analysis (CoA) and Safety Data Sheet (SDS)
- Compliance with chemical safety management under ISO 17025 or equivalent
Health and Safety Considerations
EAM-2201 exhibits potent psychoactive and toxic effects at very low doses. It is not approved for human or veterinary use. In laboratory settings, it must be handled under strict safety conditions.
| Hazard Classification (GHS) | Symbol | Safety Precaution |
|---|---|---|
| Acute Toxicity (Oral, Inhalation) | ⚠️ | Avoid exposure; use fume hood |
| Eye/Skin Irritation | ⚠️ | Wear gloves and goggles |
| Environmental Hazard | ☣️ | Prevent release into waterways |
| Chemical Stability | — | Stable under nitrogen at 2–8 °C |
Safe Handling Tips:
- Always work in a ventilated enclosure (biosafety cabinet or fume hood).
- Store securely in locked chemical cabinets with restricted access.
- Dispose of residues via licensed hazardous waste contractors.
Transactional: Global Legal and Regulatory Framework
As synthetic cannabinoids like EAM-2201 gained popularity, international agencies introduced rapid control measures.
| Region / Country | Legal Classification | Control Reference |
|---|---|---|
| United States | Schedule I (Controlled Substances Act) | DEA Final Rule, 2013 |
| European Union | Controlled psychoactive substance | EMCDDA Regulation 2020/778 |
| United Kingdom | Class B (Misuse of Drugs Act 1971) | Home Office, 2014 |
| Canada | Schedule II (Controlled Drugs and Substances Act) | Health Canada, 2015 |
| Australia | Schedule 9 (Poisons Standard 2023) | Therapeutic Goods Administration |
| China | Controlled narcotic analogue | Ministry of Public Security (2018) |
Key Takeaway:
Unlicensed possession, distribution, or sale of EAM-2201 powder is illegal in nearly all countries. However, regulated research access is permitted for institutions with recognized licenses under drug control and forensic research laws.
Environmental and Disposal Guidance
EAM-2201 and its solutions are classified as hazardous chemical waste under international environmental regulations.
Best Practice Disposal:
- Collect all residues in sealed, labeled containers.
- Dispose via incineration at >1,200 °C under emission-controlled conditions.
- Maintain disposal records per EPA 40 CFR 261-268 and EU Directive 2008/98/EC.
- Never discharge to drains or natural systems.
Comparative Overview: EAM-2201 and Related Synthetic Cannabinoids
| Compound | Formula | CB₁ Affinity | Relative Potency | Legal Status (U.S.) |
|---|---|---|---|---|
| EAM-2201 | C₂₆H₂₆FNO | High | Very high | Schedule I |
| AM-2201 | C₂₄H₂₂FNO | Very high | Extremely high | Schedule I |
| JWH-018 | C₂₄H₂₃NO | Moderate | Moderate | Schedule I |
| UR-144 | C₂₁H₂₉NO | Moderate | Moderate | Schedule I |
| AB-FUBINACA | C₂₀H₂₁FN₄O | High | Very high | Schedule I |
This comparison helps researchers understand how small structural changes in synthetic cannabinoids can significantly alter potency, metabolism, and receptor binding.
Scientific Significance
Despite its restrictions, EAM-2201 remains valuable in forensic and pharmacological research because:
- It helps identify new psychoactive substances (NPS) in seized samples.
- It supports the development of mass-spectral libraries for law enforcement.
- It informs public-health policy by mapping trends in synthetic cannabinoid usage.
Institutions studying EAM-2201 contribute to global drug surveillance and harm-reduction efforts, ensuring evidence-based regulation of psychoactive compounds.
Conclusion
EAM-2201 powder exemplifies the challenges of monitoring and managing rapidly evolving synthetic cannabinoids. While the substance is now strictly controlled, it retains scientific importance for toxicology, forensic science, and regulatory training.
By maintaining transparency, legal compliance, and analytical rigor, laboratories can responsibly study EAM-2201 and related compounds — ultimately helping to protect public safety and improve global drug-monitoring systems.
Keywords
synthetic cannabinoid research • EAM-2201 forensic analysis • cannabinoid receptor agonist • analytical toxicology stanM-2201 powderdards • GC-MS detection of EAM-2201 • EAM-2201 legal status • controlled substance reference material
- SMILES: CCC1=CC=C(C(C2=CN(CCCCCF)C3=C2C=CC=C3)=O)C4=C1C=CC=C4
- InChI Code: InChI=1S/C26H26FNO/c1-2-19-14-15-23(21-11-5-4-10-20(19)21)26(29)24-18-28(17-9-3-8-16-27)25-13-7-6-12-22(24)25/h4-7,10-15,18H,2-3,8-9,16-17H2,1H3
- InChI Key: NSCXPXDWLZORPX-UHFFFAOYSA-N
Uses:
- Research: EAM-2201 is a synthetic cannabinoid used primarily in research and forensic applications. It was first identified as an ingredient in synthetic cannabis smoking blends.
- Cannabinoid Receptor Activity: It is a potent agonist for cannabinoid receptors CB1 and CB2, with Ki values of 1.0 nM for CB1 and 2.6 nM for CB2.
Legal Status:
- United States: EAM-2201 is classified as a Schedule I Controlled Substance, making it illegal to possess, distribute, or use outside of approved research contexts.
- New Zealand: Banned as a temporary class drug since December 2012 due to concerns about addiction and psychosis.
Where to Buy:
- Online Suppliers: Look for reputable chemical suppliers who offer high-purity EAM-2201 with detailed product specifications. Ensure they comply with legal and safety regulations.
- Wholesale: Many suppliers offer options for bulk purchasing. Verify their certifications and quality assurance measures.
Important Notes:
- Research Only: EAM-2201 is intended for research purposes only and is not for human or animal consumption.
- Safety: Handle with appropriate safety gear and store according to recommended conditions to maintain stability and purity.
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Buy EAM-2201 powder online
Buy EAM-2201 powder online. EAM-2201 for sale online(4′-ethyl-AM-2201, 5″-fluoro-JWH-210) is a designer drug that belongs to the cannabinoid class. It was first identified in Japan in July 2012 as an ingredient in synthetic cannabis smoking blends. Similar to the closely related MAM-2201, EAM-2201 appears to be another compound invented by suppliers specifically for recreational use.
