Androstanolone (Dihydrotestosterone, DHT) Powder: Properties, Uses, and Legal Research Access
Introduction
Androstanolone, also known as Dihydrotestosterone (DHT), is a potent endogenous androgen derived from testosterone. It plays a critical role in male sexual development, androgenic activity, and cellular signaling.
Synthetic Androstanolone is widely used in biochemical research, receptor pharmacology, endocrine studies, and pharmaceutical development. This article provides a comprehensive overview of chemical properties, biological function, research applications, quality assurance, and legal procurement, remaining fully compliant with international regulations.
Informational: Chemical Identity and Properties
| Parameter | Specification |
|---|---|
| Chemical Name | Androstanolone |
| Synonyms | Dihydrotestosterone (DHT); 5α-Androstan-17β-ol-3-one |
| CAS Number | 521-18-6 |
| Molecular Formula | C19H30O2 |
| Molecular Weight | 290.44 g/mol |
| Appearance | White to off-white crystalline powder |
| Melting Point | 172–174 °C |
| Solubility | Soluble in ethanol, methanol, chloroform; slightly soluble in water |
| Purity | ≥ 98% (HPLC/GC) |
| Storage Conditions | –20 °C, dry, light-protected |
| Documentation | Certificate of Analysis (COA), Safety Data Sheet (SDS) |
Overview: Androstanolone is a high-purity steroidal androgen, commonly used for research into androgen receptor activity, hormone metabolism, and steroid biosynthesis.
Navigational: Biological Function and Mechanism
Androstanolone is a key androgen responsible for several physiological processes:
- Androgenic Activity: Promotes development of male sexual characteristics.
- Receptor Binding: Strong affinity for androgen receptors (AR), mediating transcription of androgen-responsive genes.
- Metabolic Role: Synthesized from testosterone via 5α-reductase, regulating hair growth, sebaceous gland activity, and prostate function.
- Medical Research Importance: Understanding DHT is crucial for androgenic alopecia, prostate disorders, and hormonal therapies.
Research with Androstanolone helps elucidate steroid hormone pathways, receptor pharmacology, and endocrine regulation.
Navigational: Research and Pharmaceutical Applications
1. Endocrinology Research
- Studying androgen receptor signaling in vitro and in vivo.
- Investigating hormone metabolism, 5α-reductase activity, and related enzymatic pathways.
2. Pharmacology and Drug Development
- Reference compound for androgen receptor agonists/antagonists.
- Assists in designing therapies for androgen deficiency, prostate conditions, and hair loss treatments.
3. Analytical and Anti-Doping Research
- Serves as a standard in GC-MS, LC-MS, and HPLC assays.
- Detects exogenous steroid use in sports and clinical research.
4. Educational Applications
- Demonstrates steroid-receptor interactions, androgen metabolism, and endocrine signaling in academic labs.
Commercial: Grades, Quality, and Supplier Selection
1. Available Grades
| Grade | Purity | Application |
|---|---|---|
| Analytical / Research Grade | ≥ 98% | Receptor studies, in vitro and in vivo assays |
| Pharmaceutical Intermediate | ≥ 99% | Drug development and synthetic pathway research |
| Bulk / Industrial Grade | 95–98% | Laboratory research and analytical studies |
2. Packaging and Handling
- Supplied in airtight, light-protected vials (1 mg – 500 g).
- Nitrogen-flushed packaging recommended for long-term stability.
- Certified suppliers provide COA, SDS, and batch traceability.
3. Quality Assurance
- Verified with HPLC, GC, NMR, or LC-MS for purity and identity.
- Free from residual solvents or degradation products.
- ISO-certified suppliers ensure consistent purity and regulatory compliance.
Transactional: Legal Supply and Compliance
Androstanolone (DHT) is a research-grade androgen, legally sold for laboratory, pharmaceutical, and analytical applications.
Regulatory Overview
| Region | Regulatory Authority | Notes / Requirements |
|---|---|---|
| United States | FDA / DEA | Controlled substance for human use; legal for research with documentation |
| European Union | EMA / REACH | Legal for research and analytical purposes |
| United Kingdom | MHRA | Legal for research; restricted for human consumption |
| Asia-Pacific | Local authorities | Permitted for laboratory and pharmaceutical research with COA/SDS |
Safe Procurement Practices
- Purchase from certified, reputable suppliers offering analytical or pharmaceutical-grade Androstanolone.
- Verify COA and SDS for purity, stability, and batch integrity.
- Store in a cool, dry, airtight, and light-protected environment.
- Use PPE including gloves, lab coat, and eye protection.
- Maintain documentation for compliance with institutional and regulatory guidelines.
Safety and Handling
| Hazard | Precaution |
|---|---|
| Bioactive Steroid | Avoid ingestion, inhalation, or skin contact |
| PPE | Gloves, protective eyewear, lab coat |
| Storage | –20 °C, dry, light-protected |
| Spills | Absorb carefully; ventilate; dispose per regulations |
| Emergency | Rinse affected area; seek medical attention if exposure occurs |
Note: Androstanolone is intended strictly for research purposes and must not be used for unapproved human administration.
Market and Research Outlook
Androstanolone continues to be in demand for:
- Endocrinology and steroid research
- Pharmaceutical development for androgen therapies
- Anti-doping and analytical laboratories
High-purity Androstanolone from certified suppliers ensures reproducibility, safety, and regulatory compliance, making it a vital tool for modern biomedical research.
Conclusion Androstanolone
Androstanolone (Dihydrotestosterone, DHT) is an essential steroidal androgen for research on hormone metabolism, receptor pharmacology, and endocrine signaling.
By sourcing from certified suppliers with COA and SDS documentation, researchers can ensure legal, safe, and effective use, making Androstanolone an indispensable compound in biochemical, pharmaceutical, and analytical studies.
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