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3-CMC (3-Chloromethcathinone) | 4-CMC Crystals: Chemical Properties, Research Applications, and Regulatory Overview

Informational Overview

            3-CMC (3-Chloromethcathinone) is a synthetic cathinone derivative, chemically related to naturally occurring cathinones. It has attracted attention in forensic toxicology, analytical chemistry, and pharmacological research due to its stimulant-like structure.

This compound is not approved for human consumption and is restricted to licensed laboratories for academic, forensic, and regulatory studies.


Chemical Structure and Properties

3-CMC features a chlorine atom at the 3-position of the phenyl ring, which affects its chemical behavior and interaction with monoamine transporters. It is primarily used as a model compound in analytical and neurochemical research.

Property Details
Chemical Name 1-(3-Chlorophenyl)-2-(methylamino)propan-1-one
CAS Number 10403-56-6 (research reference)
Molecular Formula C10H12ClNO
Molecular Weight 189.66 g/mol
Appearance White to off-white crystalline powder
Solubility Ethanol, methanol; limited water solubility
Melting Point ~205–208 °C
Pharmacological Class Substituted cathinone (stimulant derivative)
Primary Research Use Analytical, forensic, and chemical studies

Mechanism of Interest: Substituted cathinones interact with monoamine transporters, making 3-CMC valuable for structure-activity relationship (SAR) studies, forensic method development, and analytical validation.


3-CMC Crystals  Laboratory and Research Applications

Forensic Chemistry

Forensic laboratories utilize 3-CMC to:

  • Detect and identify it in seized materials using GC-MS, LC-MS, and NMR
  • Develop analytical protocols for law enforcement
  • Train chemists in synthetic cathinone identification

Academic and Pharmacological Research

Research applications include:

  • SAR studies of stimulant analogs
  • Development of trace-detection analytical methods
  • Comparative studies with other synthetic cathinones for toxicology and regulatory assessment

Safety and Controlled Environment

Given its stimulant properties and structural similarity to controlled substances:

  • Work is conducted in biosafety cabinets or fume hoods
  • Personnel use PPE: gloves, goggles, lab coat
  • Accurate weighing and containment protocols are mandatory.

 Analytical-Grade Supply and Regulatory Compliance

3-CMC is not approved for human use. Licensed laboratories may procure analytical-grade quantities under strict regulatory oversight.

Specification Typical Value
Purity ≥98% (HPLC assay)
Appearance White crystalline powder
Solubility Ethanol, methanol, acetone
Storage Sealed, desiccated container at 2–8 °C
Documentation Certificate of Analysis (CoA), MSDS, compliance papers
Regulatory Compliance Laboratory use only; controlled substance laws vary by jurisdiction

Authorized suppliers provide:

  • ISO or GLP-compliant reference standards
  • Traceable purity documentation
  • Certificates and MSDS for safe handling and regulatory adherence

3-CMC Crystals  Legal and Regulatory Considerations

Global Legal Status

Region Controlled Status
United States Synthetic cathinone analog; may fall under Schedule I analogue laws
European Union Controlled under national psychoactive substance regulations
Canada Schedule III under Controlled Drugs and Substances Act
Australia Prohibited under NPS legislation
International Monitored under UN conventions in multiple jurisdictions

Authorized Procurement

Legal access is restricted to licensed laboratories and research institutions:

  • Maintain detailed inventory logs
  • Secure storage with restricted access
  • Proper chemical waste disposal according to regulations

Unauthorized possession, distribution, or recreational use is illegal.


Safety, Handling, and Environmental Guidelines

Handling Precautions:

  • Gloves, protective clothing, and eye protection
  • Work in fume hoods or enclosed systems
  • Avoid skin contact and inhalation
  • Properly label and secure containers

Environmental Considerations:

  • Dispose of 3-CMC via hazardous chemical protocols
  • Avoid release into drains, soil, or waterways

Key Takeaways for Researchers

  • 3-CMC is strictly for research and analytical use
  • Not for human consumption
  • Legal handling requires licensed facilities
  • Documented storage, handling, and disposal are mandatory
  • Supports forensic identification, analytical method development, and regulatory research

3-CMC Keywords:3-CMC research chemical,” “synthetic cathinone analytical standards,” “3-Chloromethcathinone forensic analysis,” “controlled research substances,” “laboratory handling 


 

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