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2,5-Dimethoxybenzaldehyde: Properties, Laboratory Applications, and Regulatory Overview

Introduction

             2,5-Dimethoxybenzaldehyde is an aromatic aldehyde widely used as an intermediate in organic synthesis, aromatic compound development, and fragrance chemistry. It appears as a pale-yellow crystalline solid with a characteristic sweet, floral odor and is soluble in most organic solvents.

Due to its dual methoxy groups and aldehyde functionality, 2,5-Dimethoxybenzaldehyde exhibits high reactivity and versatility, making it valuable for chemical research, polymer science, and analytical calibration. It is a legally tradeable compound when used in laboratory or industrial contexts, but must be handled with care due to its reactive nature.

1. Informational: Chemical Identity and Structure

2,5-Dimethoxybenzaldehyde belongs to the methoxybenzaldehyde family, derivatives of benzaldehyde substituted by two methoxy (–OCH₃) groups at the 2 and 5 positions.

Its structure enhances electron density on the aromatic ring, facilitating electrophilic substitution reactions, oxidation, and condensation reactions in organic chemistry.

Chemical Properties Table

2. Navigational: Laboratory and Research Applications

Organic Synthesis Intermediate

2,5-Dimethoxybenzaldehyde is a common starting material in aromatic and heterocyclic compound synthesis. It serves as a precursor for:

• Substituted phenethylamines and benzylamines (in authorized research only)
• Polymer modifiers with aromatic stability
• Fine chemicals and aroma compounds

In condensation reactions, the aldehyde group readily reacts with amines and ketones, forming Schiff bases and chalcones used in pharmaceutical and agricultural chemistry.

Analytical and Spectroscopic Calibration

Due to its well-defined IR and NMR spectral peaks, 2,5-Dimethoxybenzaldehyde is used for instrument calibration in:

• Infrared (IR) spectroscopy — aromatic C–H and carbonyl peaks
• Nuclear Magnetic Resonance (NMR) — identifying aromatic proton shifts
• Mass spectrometry — molecular ion peak at m/z 166

Fragrance and Flavor Research

2,5-Dimethoxybenzaldehyde contributes to aromatic and floral note development in fragrance research. It’s sometimes included in perfume formulation studies, where its aldehydic tone provides a distinctive aromatic balance.

3. Commercial: Industrial and Analytical Supply

Available Grades

Packaging and Distribution

Suppliers typically offer 2,5-Dimethoxybenzaldehyde in:

• Glass bottles (25 g – 500 g) for lab use
• HDPE containers or drums (1 – 25 kg) for industrial applications

Each shipment should include:

• Certificate of Analysis (CoA)
• Safety Data Sheet (SDS)
• UN/GHS-compliant labeling

Certified suppliers operate under ISO 9001 and REACH or GHS frameworks, ensuring safety and traceability across international trade.

4. Transactional: Safe Handling, Storage, and Legal Compliance

Safety Measures

While generally stable, 2,5-Dimethoxybenzaldehyde can cause skin and eye irritation upon contact and respiratory discomfort if inhaled.
Always follow standard chemical safety protocols:

• Use gloves, goggles, and lab coats
• Operate under ventilated fume hoods
• Avoid open flames and strong oxidizing agents

Storage Recommendations

Store tightly sealed in amber glass containers at 15–25 °C, away from light and moisture.
Avoid exposure to air to prevent gradual oxidation to 2,5-Dimethoxybenzoic acid.

Waste Management

Dispose of residues through hazardous waste collection systems, not drains or general refuse. Neutralize aldehydes before disposal per local environmental regulations.

Regulatory Overview

5. Environmental and Toxicological Notes

2,5-Dimethoxybenzaldehyde exhibits low environmental persistence and is readily biodegradable under aerobic conditions.

• Oral LD₅₀ (rat): > 1,600 mg/kg
• Inhalation hazard: Low volatility; use ventilation during heating or dissolution
• Ecotoxicity: Minimal aquatic toxicity when handled correctly

Following standard laboratory hygiene eliminates occupational exposure risk.

6. Market and Research Outlook

The global demand for aromatic aldehydes like 2,5-Dimethoxybenzaldehyde is driven by growth in:

• Fine-chemical synthesis
• Perfume and flavor industries
• Analytical and photochemical laboratories

Emerging research explores green oxidation methods to produce this compound more sustainably from anisole derivatives or bio-based aromatic feedstocks, aligning with global efforts toward eco-friendly synthesis. Buy 2,5-Dimethoxybenzaldehyde reagent grade

7. Conclusion

                2,5-Dimethoxybenzaldehyde is a highly versatile and legally tradeable aromatic aldehyde used across scientific, analytical, and industrial domains.
Its combination of chemical stability, aromatic reactivity, and distinctive odor profile makes it indispensable for:

• Organic synthesis
• Spectroscopic calibration
• Fine-chemical development

When procured from certified suppliers and handled under standard chemical safety procedures, it serves as a reliable and compliant reagent for modern laboratories worldwide.

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Applications:

• Organic Synthesis: Used as an intermediate in the preparation of various psychoactive compounds, including 2,5-dimethoxyphenethylamine (2C-H), which is further used to produce substances like 2C-B, 2C-I, and 2C-C.
• Pharmaceutical Intermediate: Utilized in the production of compounds for research and industrial purposes.

Ordering Information:

• Packaging: Typically available in 25 kg drums.
• Delivery Time: Approximately 7 days.
• Port: Shanghai

Price and Wholesale Information:

• Wholesale Supply: Available with a production capacity of 50 metric tons per month.
• Minimum Order Quantity: 1 kilogram
• Wholesale Price: Contact suppliers for specific pricing details.

Safety and Handling:

• Air Sensitive: Store in a dry, cool environment to prevent degradation.
• Incompatibility: Avoid contact with strong oxidizing agents.
• Usage: Generally used for research and industrial applications, not for human consumption.

Purchasing Notes:

• Ensure Compliance: Verify that your purchase complies with local regulations.
• Quality Assurance: Confirm that the product meets your quality requirements before purchasing.

Where to Buy:

For high-quality 2,5-Dimethoxybenzaldehyde, consider reaching out to reputable suppliers and manufacturers who offer competitive pricing and secure delivery options.