Buy Wholesale Melittin/Bee Venom Melittin/Forapine CAS No. 20449-79-0 at Factory Prices
Melittin, the primary active component of honeybee (Apis mellifera) venom, constitutes 40-60% of the venom’s dry weight and is responsible for the pain and tissue damage caused by bee stings. It is a basic peptide composed of 26 amino acids and is the major pain-inducing agent in bee venom. In addition to its role in bee defense, melittin plays a part in the honeybee’s immune response by being overexpressed in other tissues when infected with pathogens.
Functions and Mechanism of Action of Melittin
- Pain and Tissue Destruction: Melittin’s primary biological function is to defend the hive by causing pain and tissue damage in intruders. It achieves this by integrating into cell membranes, forming pores, and causing cell destruction, including the breakdown of red blood cells.
- Immune Response: https://lilcentglobalmedicalpharmacy.com/product/bizarro-herbal-incense/Melittin and secapin, another venom molecule, are upregulated in honeybees when they are infected by pathogens, suggesting melittin plays a role in the bee’s immune response.
- Cellular Action: Melittin disrupts cell membranes and activates pain receptors (nociceptors), which leads to an inflammatory response. It opens TRPV1 channels in pain receptor cells via cyclooxygenase metabolites, resulting in cell depolarization and pain. It also increases the expression of sodium channels Nav1.8 and Nav1.9, which heightens long-term pain sensation.
- Inhibition of Enzymes and Pumps: Melittin inhibits several protein kinases (e.g., protein kinase C and Ca2+/calmodulin-dependent protein kinase II) and blocks transport pumps such as Na+-K+-ATPase, contributing to its broad range of biological effects.
Toxicity and Effects of Bee Stings
Melittin is the main toxic compound in bee venom and is responsible for the potential lethality of bee stings, particularly in individuals allergic to bee venom. For such people, bee stings can cause anaphylactic reactions, leading to life-threatening symptoms. Non-allergic individuals may experience pain, redness, and swelling at the sting site.
Quick Details for Melittin/Bee Venom Melittin/Forapine
- Classification: Other Inorganic Chemicals
- CAS Number: 20449-79-0
- Molecular Formula: C131H229N39O31
- EINECS Number: 253-417-7
- Purity: 98%
- Appearance: White powder
- Refractive Index: 1.635
- Uses: Animal pharmaceuticals and research
Packaging and Delivery
- Packaging: Available in 25kg/bag
- Delivery Time: 3-5 days after order confirmation
- Storage: Store in a cool, dry place away from moisture and direct sunlight.
Product Benefits and Supplier Advantages
- High Quality and Strict Control: Collaboration with research institutions ensures strict quality control from raw materials to the final product.
- Competitive Prices: Offering reasonable prices, high-quality products, and timely shipments.
- Safe and Fast Shipping: Goods can be shipped directly to the customer’s address with safety and speed ensured. Ready stock is available for immediate dispatch.
- Responsive Customer Service: Prompt and clear responses to customer inquiries, along with dedicated after-sale support to solve any product-related issues.
- Discount on Bulk Orders: Special price discounts are available for substantial order quantities.
Key Suppliers and Sources:
- Wholesale Price Extract Powder Bee Venom/Melittin
- Lilcent Global Medical Pharmacy: Melittin as a Phospholipase (e.g., PLA) activator
- Toronto Research Chemicals: Melittin CAS 20449-79-0
- PubChem: Melittin (C131H229N39O31) for research purposes
- Latoxan Valence France: High-purity melittin for research and pharmaceutical use
- Custom Peptide Suppliers: Offering high-purity melittin for research at competitive factory prices.
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